Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 372.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.43 mL||26.87 mL|
|5 mM||0.54 mL||2.69 mL||5.37 mL|
|10 mM||0.27 mL||1.34 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the products' biological activity.
Nozaki et al (2004) Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195 PMID: 14758089
Kyoi et al (2004) Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95 321 PMID: 15272207
Kyoi et al (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76 71 PMID: 15501481
If you know of a relevant reference for Irsogladine maleate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Irsogladine maleate, supplier, PDE4, inhibitors, inhibits, antiulcer, agent, Phosphodiesterases, MN1695, MN, 1695, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
Citations for Irsogladine maleate
Citations are publications that use Tocris products.
Currently there are no citations for Irsogladine maleate. Do you know of a great paper that uses Irsogladine maleate from Tocris? If so please let us know.
Irsogladine maleate Reviews
Average Rating:(Based on 0 Reviews)