Irsogladine maleate

Pricing Availability Delivery Time Qty
Cat.No. 2504 - Irsogladine maleate | C9H7Cl2N5.C4H4O4 | CAS No. 84504-69-8
Description: PDE4 inhibitor; antiulcer agent
Alternative Names: MN 1695
Chemical Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
Purity: ≥99% (HPLC)

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Compound Libraries

Irsogladine maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 372.18
Formula C9H7Cl2N5.C4H4O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 84504-69-8
PubChem ID 5282435
Smiles OC(=O)\C=C/C(O)=O.NC1=NC(=NC(N)=N1)C1=CC(Cl)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.22 100
ethanol 37.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 372.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.43 mL 26.87 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Nozaki et al (2004) Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195 PMID: 14758089

Kyoi et al (2004) Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95 321 PMID: 15272207

Kyoi et al (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76 71 PMID: 15501481

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Keywords: Irsogladine maleate, supplier, PDE4, inhibitors, inhibits, antiulcer, agent, Phosphodiesterases, MN1695, MN, 1695, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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