IRL-1038

Pricing Availability   Qty
Cat.No. 1195 - IRL-1038 | Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: 1 - 5) | CAS No. 144602-02-8
Description: ETB antagonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

ETB endothelin receptor antagonist.

Technical Data

M. Wt 1410
Formula C68H92N14O15S2
Sequence CVYFCHLDIIW

(Modifications: Disulfide bridge between 1 - 5)

Storage Desiccate at -20°C
CAS Number 144602-02-8
PubChem ID 16142511
InChI Key OETKRDJJNWJFOP-PJLZVMSOSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 20% acetonitrile

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Haynes et al (1993) Endothelin; progress in pharmacology and physiology. TiPS 14 225 PMID: 8372400

Karaki et al (1993) ETB receptor antagonist, IRL 1038, selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation. Eur.J.Pharmacol. 231 371 PMID: 8449230


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Keywords: IRL-1038, IRL-1038 supplier, ETB, antagonists, Receptors, Endothelin, 1195, Tocris Bioscience

1 Citation for IRL-1038

Citations are publications that use Tocris products. Selected citations for IRL-1038 include:

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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