IRL-1038

Pricing Availability Delivery Time Qty
Cat.No. 1195 - IRL-1038 | Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: 1 - 5) | CAS No. 144602-02-8
Description: ETB antagonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

ETB endothelin receptor antagonist.

Technical Data

M. Wt 1410
Formula C68H92N14O15S2
Sequence CVYFCHLDIIW

(Modifications: Disulfide bridge between 1 - 5)

Storage Desiccate at -20°C
CAS Number 144602-02-8
PubChem ID 16142511
InChI Key OETKRDJJNWJFOP-PJLZVMSOSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile

Preparing Stock Solutions

The following data is based on the product molecular weight 1410. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.71 mL 3.55 mL 7.09 mL
5 mM 0.14 mL 0.71 mL 1.42 mL
10 mM 0.07 mL 0.35 mL 0.71 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Haynes et al (1993) Endothelin; progress in pharmacology and physiology. TiPS 14 225 PMID: 8372400

Karaki et al (1993) ETB receptor antagonist, IRL 1038, selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation. Eur.J.Pharmacol. 231 371 PMID: 8449230


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Keywords: IRL-1038, supplier, ETB, antagonists, Receptors, Endothelin, Endothelin, ETB, Receptors, Endothelin, ETB, Receptors, Tocris Bioscience

1 Citation for IRL-1038

Citations are publications that use Tocris products. Selected citations for IRL-1038 include:

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510


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