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Submit ReviewIRAK1/4 Inhibitor I is an IRAK4 and IRAK1 inhibitor (IC50 values are 0.2 and 0.3 μM, respectively).
IRAK1/4 Inhibitor I is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
M. Wt | 395.41 |
Formula | C20H21N5O4 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 509093-47-4 |
PubChem ID | 11983295 |
InChI Key | QTCFYQHZJIIHBS-UHFFFAOYSA-N |
Smiles | O=C(NC1=NC(C=CC=C2)=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.91 | 20 |
The following data is based on the product molecular weight 395.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 12.65 mL | 63.23 mL | 126.45 mL |
1 mM | 2.53 mL | 12.65 mL | 25.29 mL |
2 mM | 1.26 mL | 6.32 mL | 12.65 mL |
10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
References are publications that support the biological activity of the product.
Powers et al (2006) Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg.Med.Chem.Lett. 16 2842 PMID: 16563752
If you know of a relevant reference for IRAK1/4 Inhibitor I, please let us know.
Keywords: IRAK1/4 Inhibitor I, IRAK1/4 Inhibitor I supplier, IRAK1/4, inhibitors, inhibits, I, interleukin-1, receptor, associated, kinase, IRAK, 5665, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for IRAK1/4 Inhibitor I. Do you know of a great paper that uses IRAK1/4 Inhibitor I from Tocris? Please let us know.
Average Rating: 5 (Based on 1 Review.)
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