IRAK1/4 Inhibitor I

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Cat.No. 5665 - IRAK1/4 Inhibitor I | C20H21N5O4 | CAS No. 509093-47-4
Description: IRAK4 and IRAK1 inhibitor
Chemical Name: N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

IRAK4 and IRAK1 inhibitor (IC50 values are 0.2 and 0.3 μM, respectively).

Technical Data

M. Wt 395.41
Formula C20H21N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 509093-47-4
PubChem ID 11983295
InChI Key QTCFYQHZJIIHBS-UHFFFAOYSA-N
Smiles O=C(NC1=NC(C=CC=C2)=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.91 20

Preparing Stock Solutions

The following data is based on the product molecular weight 395.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.65 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Powers et al (2006) Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg.Med.Chem.Lett. 16 2842 PMID: 16563752


If you know of a relevant reference for IRAK1/4 Inhibitor I, please let us know.

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Citations for IRAK1/4 Inhibitor I

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for IRAK1/4 Inhibitor I

Protocols

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