IPSU

Discontinued Product

IPSU (Cat. No. 5645) has been withdrawn from sale for commercial reasons.
Cat.No. 5645 - IPSU | C23H27N5O2 | CAS No. 1373765-19-5
Description: OX2 antagonist; orally bioavailable
Chemical Name: 2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for IPSU

OX2 receptor antagonist. Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.

Technical Data for IPSU

M. Wt 405.49
Formula C23H27N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1373765-19-5
PubChem ID 56970858
InChI Key PCMHOSYCWRRHTG-UHFFFAOYSA-N
Smiles COC1=CC=NC(N2CCC3(C(N(CC4=CNC5=C4C=CC=C5)CCC3)=O)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for IPSU

References are publications that support the biological activity of the product.

Hoyer et al (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front.Neurosci. 7 230 PMID: 24376396

Betschart et al (2013) Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J.Med.Chem. 56 7590 PMID: 23964859

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Keywords: IPSU, IPSU supplier, OX2, receptors, antagonists, antagonism, orexins, sleep, orally, bioavailable, brain, penetrant, Receptor, 5645, Tocris Bioscience

Citations for IPSU

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Currently there are no citations for IPSU.

Reviews for IPSU

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Literature in this Area

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