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OX2 receptor antagonist. Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 405.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.47 mL||12.33 mL||24.66 mL|
|5 mM||0.49 mL||2.47 mL||4.93 mL|
|10 mM||0.25 mL||1.23 mL||2.47 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References are publications that support the biological activity of the product.
Hoyer et al (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front.Neurosci. 7 230 PMID: 24376396
Betschart et al (2013) Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J.Med.Chem. 56 7590 PMID: 23964859
If you know of a relevant reference for IPSU, please let us know.
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Keywords: IPSU, IPSU supplier, OX2, receptors, antagonists, antagonism, orexins, sleep, orally, bioavailable, brain, penetrant, Receptor, 5645, Tocris Bioscience
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