Discontinued Product

IPSU (Cat. No. 5645) has been withdrawn from sale for commercial reasons.
Description: OX2 antagonist; orally bioavailable
Chemical Name: 2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for IPSU

OX2 receptor antagonist. Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.

Technical Data for IPSU

M. Wt 405.49
Formula C23H27N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1373765-19-5
PubChem ID 56970858
Smiles COC1=CC=NC(N2CCC3(C(N(CC4=CNC5=C4C=CC=C5)CCC3)=O)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for IPSU

References are publications that support the biological activity of the product.

Hoyer et al (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front.Neurosci. 7 230 PMID: 24376396

Betschart et al (2013) Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J.Med.Chem. 56 7590 PMID: 23964859

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Keywords: IPSU, IPSU supplier, OX2, receptors, antagonists, antagonism, orexins, sleep, orally, bioavailable, brain, penetrant, Receptor, 5645, Tocris Bioscience

Citations for IPSU

Citations are publications that use Tocris products.

Currently there are no citations for IPSU.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.