IPSU

Pricing Availability Delivery Time Qty
Cat.No. 5645 - IPSU | C23H27N5O2 | CAS No. 1373765-19-5
Description: OX2 receptor antagonist; orally bioavailable
Chemical Name: 2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

OX2 receptor antagonist. Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.

Technical Data

M. Wt 405.49
Formula C23H27N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1373765-19-5
PubChem ID 56970858
InChI Key PCMHOSYCWRRHTG-UHFFFAOYSA-N
Smiles COC1=CC=NC(N2CCC3(C(N(CC4=CNC5=C4C=CC=C5)CCC3)=O)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 40.55 100
DMSO 40.55 100
ethanol 20.27 50

Preparing Stock Solutions

The following data is based on the product molecular weight 405.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.33 mL 24.66 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hoyer et al (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front.Neurosci. 7 230 PMID: 24376396

Betschart et al (2013) Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J.Med.Chem. 56 7590 PMID: 23964859


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Keywords: OX2 receptors antagonists antagonism orexins sleep orally bioavailable brain penetrant OX2 Receptor

Citations for IPSU

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Pathways for IPSU

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