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Biological Activity for IPAG
IPAG is a potent σ-receptor antagonist.
Technical Data for IPAG
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for IPAG
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for IPAG
The following data is based on the product molecular weight 395.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.65 mL||25.3 mL|
|5 mM||0.51 mL||2.53 mL||5.06 mL|
|10 mM||0.25 mL||1.26 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References for IPAG
References are publications that support the biological activity of the product.
Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571
Wilson et al (1991) Radiosynthesis of σ receptor ligands for positron emission tomography: 11C- and 18F-labelled guanidines. J.Med.Chem. 34 1867 PMID: 1648140
If you know of a relevant reference for IPAG, please let us know.
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Keywords: IPAG, IPAG supplier, Potent, σ, sigma, antagonists, General, Receptors, Sigma-Related, 0544, Tocris Bioscience
2 Citations for IPAG
Citations are publications that use Tocris products. Selected citations for IPAG include:
Brimson et al (2011) Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol 164 772 PMID: 21486275
Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888
Do you know of a great paper that uses IPAG from Tocris? Please let us know.
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