IPAG

Pricing Availability Delivery Time Qty
Cat.No. 0544 - IPAG | C17H22IN3 | CAS No. 193527-91-2
Description: Potent σ antagonist
Chemical Name: 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent σ-receptor antagonist.

Technical Data

M. Wt 395.29
Formula C17H22IN3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 193527-91-2
PubChem ID 4239764
InChI Key UUKPIWYXWLJPJF-UHFFFAOYSA-N
Smiles IC1=CC=C(NC(=N)NC2C3CC4CC(C3)CC2C4)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in ethanol and to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 395.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.65 mL 25.3 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571

Wilson et al (1991) Radiosynthesis of σ receptor ligands for positron emission tomography: 11C- and 18F-labelled guanidines. J.Med.Chem. 34 1867 PMID: 1648140


If you know of a relevant reference for IPAG, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sigma-Related Antagonists

Keywords: IPAG, supplier, Potent, σ, sigma, antagonists, General, Receptors, Sigma-Related, Sigma-Related, Tocris Bioscience

1 Citation for IPAG

Citations are publications that use Tocris products. Selected citations for IPAG include:

Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888


Do you know of a great paper that uses IPAG from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for IPAG

Protocols

TODO: Add Protocols