IPAG

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Cat.No. 0544 - IPAG | C17H22IN3 | CAS No. 193527-91-2
Description: Potent σ antagonist
Chemical Name: 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Potent σ-receptor antagonist.

Technical Data

M. Wt 395.29
Formula C17H22IN3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 193527-91-2
PubChem ID 4239764
InChI Key UUKPIWYXWLJPJF-UHFFFAOYSA-N
Smiles IC1=CC=C(NC(=N)NC2C3CC4CC(C3)CC2C4)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 50
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.65 mL 25.3 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571

Wilson et al (1991) Radiosynthesis of σ receptor ligands for positron emission tomography: 11C- and 18F-labelled guanidines. J.Med.Chem. 34 1867 PMID: 1648140


If you know of a relevant reference for IPAG, please let us know.

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Keywords: IPAG, IPAG supplier, Potent, σ, sigma, antagonists, General, Receptors, Sigma-Related, 0544, Tocris Bioscience

2 Citations for IPAG

Citations are publications that use Tocris products. Selected citations for IPAG include:

Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888

Brimson et al (2011) Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol 164 772 PMID: 21486275


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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