Pricing Availability   Qty
Description: Potent σ antagonist
Chemical Name: 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for IPAG

IPAG is a potent σ-receptor antagonist.

Technical Data for IPAG

M. Wt 395.29
Formula C17H22IN3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 193527-91-2
PubChem ID 4239764
Smiles IC1=CC=C(NC(=N)NC2C3CC4CC(C3)CC2C4)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IPAG

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 50
DMSO 100

Preparing Stock Solutions for IPAG

The following data is based on the product molecular weight 395.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.65 mL 25.3 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for IPAG

Certificate of Analysis / Product Datasheet
Select another batch:

References for IPAG

References are publications that support the biological activity of the product.

Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571

Wilson et al (1991) Radiosynthesis of σ receptor ligands for positron emission tomography: 11C- and 18F-labelled guanidines. J.Med.Chem. 34 1867 PMID: 1648140

If you know of a relevant reference for IPAG, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sigma-Related Antagonists

Keywords: IPAG, IPAG supplier, Potent, σ, sigma, antagonists, General, Receptors, Sigma-Related, 0544, Tocris Bioscience

2 Citations for IPAG

Citations are publications that use Tocris products. Selected citations for IPAG include:

Brimson et al (2011) Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol 164 772 PMID: 21486275

Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888

Do you know of a great paper that uses IPAG from Tocris? Please let us know.

Reviews for IPAG

There are currently no reviews for this product. Be the first to review IPAG and earn rewards!

Have you used IPAG?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review