Pricing Availability   Qty
Description: Negative control for iP300w (Cat. No. 7270)
Chemical Name: (1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for iP300v

iP300v is a negative control for iP300w (Cat. No. 7270)

Technical Data for iP300v

M. Wt 618.55
Formula C29H27F5N6O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2763218-94-4
Smiles O=C(NC)CN(N=C1)C=C1C(C=C2)=CC3=C2[C@](N4)(C[C@@H]3F)C(N(CC(N(CC5=CC=C(F)C=C5)[C@@H](C)C(F)(F)F)=O)C4=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for iP300v

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 61.85 100

Preparing Stock Solutions for iP300v

The following data is based on the product molecular weight 618.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.08 mL 16.17 mL
5 mM 0.32 mL 1.62 mL 3.23 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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References for iP300v

References are publications that support the biological activity of the product.

Bosnakovski et al (2019) A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Sci.Adv. 5 eaaw7781 PMID: 31535023

Bosnakovski et al (2021) Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma. Oncogenesis 10 68

If you know of a relevant reference for iP300v, please let us know.

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Keywords: iP300v, iP300v supplier, HAT, Histone, Acetyltransferases, KAT, Lysine, Aceyltransferases, p300, CBP, negative, control, 7584, Tocris Bioscience

Citations for iP300v

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