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Irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)|
References are publications that support the biological activity of the product.
Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442
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Keywords: INF 39, INF 39 supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, pyroptosis, Inflammasomes, 6341, Tocris Bioscience
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