Irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 224.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.45 mL||22.25 mL||44.51 mL|
|5 mM||0.89 mL||4.45 mL||8.9 mL|
|10 mM||0.45 mL||2.23 mL||4.45 mL|
|50 mM||0.09 mL||0.45 mL||0.89 mL|
References are publications that support the products' biological activity.
Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442
If you know of a relevant reference for INF 39, please let us know.
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Keywords: INF 39, supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, Inflammasomes, Inflammasomes, Tocris Bioscience
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