Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewINF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.
M. Wt | 224.68 |
Formula | C12H13ClO2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 866028-26-4 |
PubChem ID | 69150705 |
InChI Key | VTAOWWAFBSFWSG-UHFFFAOYSA-N |
Smiles | CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
References are publications that support the biological activity of the product.
Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442
If you know of a relevant reference for INF 39, please let us know.
Keywords: INF 39, INF 39 supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, pyroptosis, Inflammasomes, 6341, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for INF 39. Do you know of a great paper that uses INF 39 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review INF 39 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image