INF 39

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Cat.No. 6341 - INF 39 | C12H13ClO2 | CAS No. 866028-26-4
Description: Irreversible NLRP3 inhibitor
Chemical Name: Ethyl 2-(2-chlorobenzyl)acrylate
Purity: ≥98% (HPLC)

Biological Activity

Irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.

Technical Data

M. Wt 224.68
Formula C12H13ClO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 866028-26-4
PubChem ID 69150705
Smiles CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 224.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.45 mL 22.25 mL 44.51 mL
5 mM 0.89 mL 4.45 mL 8.9 mL
10 mM 0.45 mL 2.23 mL 4.45 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442

If you know of a relevant reference for INF 39, please let us know.

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Keywords: INF 39, supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, Inflammasomes, Inflammasomes, Tocris Bioscience

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Literature in this Area

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