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Description: Irreversible NLRP3 inhibitor
Chemical Name: Ethyl 2-(2-chlorobenzyl)acrylate
Purity: ≥98% (HPLC)
Biological Activity for INF 39
INF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.
Technical Data for INF 39
| M. Wt | 224.68 |
| Formula | C12H13ClO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 866028-26-4 |
| PubChem ID | 69150705 |
| InChI Key | VTAOWWAFBSFWSG-UHFFFAOYSA-N |
| Smiles | CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for INF 39
| Solubility | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
Product Datasheets for INF 39
References for INF 39
References are publications that support the biological activity of the product.
Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442
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Keywords: INF 39, INF 39 supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, pyroptosis, Inflammasomes, 6341, Tocris Bioscience
Citations for INF 39
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