INF 39

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Description: Irreversible NLRP3 inhibitor
Chemical Name: Ethyl 2-(2-chlorobenzyl)acrylate
Purity: ≥98% (HPLC)

Biological Activity for INF 39

INF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.

Technical Data for INF 39

M. Wt 224.68
Formula C12H13ClO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 866028-26-4
PubChem ID 69150705
Smiles CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for INF 39

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

References for INF 39

References are publications that support the biological activity of the product.

Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442

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Citations for INF 39

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