Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewINF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.
M. Wt | 224.68 |
Formula | C12H13ClO2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 866028-26-4 |
PubChem ID | 69150705 |
InChI Key | VTAOWWAFBSFWSG-UHFFFAOYSA-N |
Smiles | CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442
Keywords: INF 39, INF 39 supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, pyroptosis, Inflammasomes, 6341, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for INF 39.
There are currently no reviews for this product. Be the first to review INF 39 and earn rewards!
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image