Immethridine dihydrobromide

Pricing Availability   Qty
Description: Potent H3 agonist, highly selective over H4
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)pyridine dihydrobromide
Purity: ≥99% (HPLC)
Reviews (1)
Literature (2)

Biological Activity for Immethridine dihydrobromide

Immethridine dihydrobromide is a potent and highly selective histamine H3 receptor agonist (pEC50 = 9.74) that displays 300-fold selectivity over the H4 receptor (pKi values are 9.07 and 6.61 respectively). Does not bind to H1 or H2 receptors at concentrations up to 10 μM..

Technical Data for Immethridine dihydrobromide

M. Wt 321.01
Formula C9H9N3.2HBr
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 699020-93-4
PubChem ID 16759172
Smiles Br.Br.C(C1=CN=CN1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Immethridine dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 32.1 100

Preparing Stock Solutions for Immethridine dihydrobromide

The following data is based on the product molecular weight 321.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.58 mL 31.15 mL
5 mM 0.62 mL 3.12 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets for Immethridine dihydrobromide

Certificate of Analysis / Product Datasheet
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References for Immethridine dihydrobromide

References are publications that support the biological activity of the product.

Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383

If you know of a relevant reference for Immethridine dihydrobromide, please let us know.

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Keywords: Immethridine dihydrobromide, Immethridine dihydrobromide supplier, Potent, H3, agonists, selective, over, H4, Receptors, Histamine, histaminergic, 2315, Tocris Bioscience

Citations for Immethridine dihydrobromide

Citations are publications that use Tocris products.

Currently there are no citations for Immethridine dihydrobromide. Do you know of a great paper that uses Immethridine dihydrobromide from Tocris? Please let us know.

Reviews for Immethridine dihydrobromide

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H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide.
By Anonymous on 12/24/2019
Species: Human

H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide. How H3 receptor targeting may help in autoimmune was the aim for the study. Excellent product.Ideal results obtained.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.