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Submit ReviewImmethridine dihydrobromide
Description: Potent H3 agonist, highly selective over H4
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)pyridine dihydrobromide
Purity: ≥99% (HPLC)
Biological Activity for Immethridine dihydrobromide
Immethridine dihydrobromide is a potent and highly selective histamine H3 receptor agonist (pEC50 = 9.74) that displays 300-fold selectivity over the H4 receptor (pKi values are 9.07 and 6.61 respectively). Does not bind to H1 or H2 receptors at concentrations up to 10 μM..
Technical Data for Immethridine dihydrobromide
| M. Wt | 321.01 |
| Formula | C9H9N3.2HBr |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 699020-93-4 |
| PubChem ID | 16759172 |
| InChI Key | CYNKWHIKNDIVDR-UHFFFAOYSA-N |
| Smiles | Br.Br.C(C1=CN=CN1)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Immethridine dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.1 | 100 |
Preparing Stock Solutions for Immethridine dihydrobromide
The following data is based on the product molecular weight 321.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.58 mL | 31.15 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.23 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for Immethridine dihydrobromide
References for Immethridine dihydrobromide
References are publications that support the biological activity of the product.
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
If you know of a relevant reference for Immethridine dihydrobromide, please let us know.
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Keywords: Immethridine dihydrobromide, Immethridine dihydrobromide supplier, Potent, H3, agonists, selective, over, H4, Receptors, Histamine, histaminergic, 2315, Tocris Bioscience
Citations for Immethridine dihydrobromide
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Reviews for Immethridine dihydrobromide
Average Rating: 5 (Based on 1 Review.)
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H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide.
By
Anonymous on 12/24/2019
Species: Human
H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide. How H3 receptor targeting may help in autoimmune was the aim for the study. Excellent product.Ideal results obtained.
Literature in this Area
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Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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