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Submit ReviewImmethridine dihydrobromide is a potent and highly selective histamine H3 receptor agonist (pEC50 = 9.74) that displays 300-fold selectivity over the H4 receptor (pKi values are 9.07 and 6.61 respectively). Does not bind to H1 or H2 receptors at concentrations up to 10 μM..
M. Wt | 321.01 |
Formula | C9H9N3.2HBr |
Storage | Desiccate at RT |
Purity | ≥99% (HPLC) |
CAS Number | 699020-93-4 |
PubChem ID | 16759172 |
InChI Key | CYNKWHIKNDIVDR-UHFFFAOYSA-N |
Smiles | Br.Br.C(C1=CN=CN1)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 32.1 | 100 |
The following data is based on the product molecular weight 321.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.12 mL | 15.58 mL | 31.15 mL |
5 mM | 0.62 mL | 3.12 mL | 6.23 mL |
10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
References are publications that support the biological activity of the product.
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
If you know of a relevant reference for Immethridine dihydrobromide, please let us know.
Keywords: Immethridine dihydrobromide, Immethridine dihydrobromide supplier, Potent, H3, agonists, selective, over, H4, Receptors, Histamine, histaminergic, 2315, Tocris Bioscience
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Average Rating: 5 (Based on 1 Review.)
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H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide. How H3 receptor targeting may help in autoimmune was the aim for the study. Excellent product.Ideal results obtained.