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Biological Activity for Immepip dihydrobromide
Immepip dihydrobromide is a potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.
Technical Data for Immepip dihydrobromide
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Immepip dihydrobromide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Immepip dihydrobromide
The following data is based on the product molecular weight 327.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.06 mL||15.29 mL||30.58 mL|
|5 mM||0.61 mL||3.06 mL||6.12 mL|
|10 mM||0.31 mL||1.53 mL||3.06 mL|
|50 mM||0.06 mL||0.31 mL||0.61 mL|
Product Datasheets for Immepip dihydrobromide
References for Immepip dihydrobromide
References are publications that support the biological activity of the product.
Coruzzi et al (1995) Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 351 569 PMID: 7675114
Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420 PMID: 11179434
Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist. J.Med.Chem. 37 332 PMID: 8308858
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Keywords: Immepip dihydrobromide, Immepip dihydrobromide supplier, H4, H3, agonists, Receptors, Histamine, histaminergic, 0932, Tocris Bioscience
1 Citation for Immepip dihydrobromide
Citations are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:
Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423
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Reviews for Immepip dihydrobromide
Average Rating: 5 (Based on 1 Review.)
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To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.
We applied 50 μM immepip and histamine to the dissociated DRG neurons in a chamber perfusion solution.
Literature in this Area
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.