Immepip dihydrobromide

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Cat.No. 0932 - Immepip dihydrobromide | C9H15N3.2HBr | CAS No. 164391-47-3
Description: Standard H3 agonist. Also H4 agonist
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Datasheet
Citations (1)
Reviews (1)
Literature (4)

Biological Activity

Potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.

Technical Data

M. Wt 327.06
Formula C9H15N3.2HBr
Storage Desiccate at RT
CAS Number 164391-47-3
PubChem ID 22315065
InChI Key YGNJPNRDGXJQJX-UHFFFAOYSA-N
Smiles Br.Br.C(C1CCNCC1)C1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 32.71 100

Preparing Stock Solutions

The following data is based on the product molecular weight 327.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.29 mL 30.58 mL
5 mM 0.61 mL 3.06 mL 6.12 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Coruzzi et al (1995) Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 351 569 PMID: 7675114

Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420 PMID: 11179434

Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist. J.Med.Chem. 37 332 PMID: 8308858


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View all Histamine H3 Receptor Agonists

Keywords: Immepip dihydrobromide, Immepip dihydrobromide supplier, H4, H3, agonists, Receptors, Histamine, histaminergic, 0932, Tocris Bioscience

1 Citation for Immepip dihydrobromide

Citations are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423


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Reviews for Immepip dihydrobromide

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Study of H4 receptor in the DGR neurons.
By Anonymous on 12/24/2019
Species: Human

To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.

We applied 50 μM immepip and histamine to the dissociated DRG neurons in a chamber perfusion solution.

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