Immepip dihydrobromide

Pricing Availability   Qty
Description: Standard H3 agonist. Also H4 agonist
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Citations (1)
Reviews (1)
Literature (2)

Biological Activity for Immepip dihydrobromide

Immepip dihydrobromide is a potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.

Technical Data for Immepip dihydrobromide

M. Wt 327.06
Formula C9H15N3.2HBr
Storage Desiccate at RT
CAS Number 164391-47-3
PubChem ID 22315065
Smiles Br.Br.C(C1CCNCC1)C1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Immepip dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 32.71 100

Preparing Stock Solutions for Immepip dihydrobromide

The following data is based on the product molecular weight 327.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.29 mL 30.58 mL
5 mM 0.61 mL 3.06 mL 6.12 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets for Immepip dihydrobromide

Certificate of Analysis / Product Datasheet
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References for Immepip dihydrobromide

References are publications that support the biological activity of the product.

Coruzzi et al (1995) Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 351 569 PMID: 7675114

Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420 PMID: 11179434

Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist. J.Med.Chem. 37 332 PMID: 8308858

If you know of a relevant reference for Immepip dihydrobromide, please let us know.

View Related Products by Product Action

View all Histamine H3 Receptor Agonists

Keywords: Immepip dihydrobromide, Immepip dihydrobromide supplier, H4, H3, agonists, Receptors, Histamine, histaminergic, 0932, Tocris Bioscience

1 Citation for Immepip dihydrobromide

Citations are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423

Do you know of a great paper that uses Immepip dihydrobromide from Tocris? Please let us know.

Reviews for Immepip dihydrobromide

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Study of H4 receptor in the DGR neurons.
By Anonymous on 12/24/2019
Species: Human

To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.

We applied 50 μM immepip and histamine to the dissociated DRG neurons in a chamber perfusion solution.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.