Imetit dihydrobromide

Pricing Availability   Qty
Description: Standard H3 and H4 agonist (H3 > H4)
Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity: ≥98% (HPLC)
Citations (3)
Literature (2)

Biological Activity for Imetit dihydrobromide

Imetit dihydrobromide is an an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

Technical Data for Imetit dihydrobromide

M. Wt 332.06
Formula C6H10N4S.2HBr
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 32385-58-3
PubChem ID 11957573
Smiles Br.Br.NC(=N)SCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Imetit dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 33.21 100

Preparing Stock Solutions for Imetit dihydrobromide

The following data is based on the product molecular weight 332.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.06 mL 30.12 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Imetit dihydrobromide

Certificate of Analysis / Product Datasheet
Select another batch:

References for Imetit dihydrobromide

References are publications that support the biological activity of the product.

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276

Garbarg et al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J.Pharmacol.Exp.Ther. 263 304 PMID: 1383495

Ling et al (2004) Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 142 161 PMID: 15131002

If you know of a relevant reference for Imetit dihydrobromide, please let us know.

View Related Products by Product Action

View all Histamine H3 Receptor Agonists

Keywords: Imetit dihydrobromide, Imetit dihydrobromide supplier, H3, H4, agonists, Receptors, Histamine, histaminergic, 0729, Tocris Bioscience

3 Citations for Imetit dihydrobromide

Citations are publications that use Tocris products. Selected citations for Imetit dihydrobromide include:

Hashikawa-Hobara et al (2012) Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. Evid Based Complement Alternat Med 340 185 PMID: 22011436

Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809

Yoshimoto et al (2006) Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A 103 13866 PMID: 16954192

Do you know of a great paper that uses Imetit dihydrobromide from Tocris? Please let us know.

Reviews for Imetit dihydrobromide

There are currently no reviews for this product. Be the first to review Imetit dihydrobromide and earn rewards!

Have you used Imetit dihydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.