Imetit dihydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 0729 - Imetit dihydrobromide | C6H10N4S.2HBr | CAS No. 32385-58-3
Description: Standard H3 and H4 agonist (H3 > H4)
Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H3 Receptor Tocriset™.

Technical Data

M. Wt 332.06
Formula C6H10N4S.2HBr
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 32385-58-3
PubChem ID 11957573
InChI Key DOBOYMKCRRLTRF-UHFFFAOYSA-N
Smiles Br.Br.NC(=N)SCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.06 mL 30.12 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276

Garbarg et al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J.Pharmacol.Exp.Ther. 263 304 PMID: 1383495

Ling et al (2004) Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 142 161 PMID: 15131002


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Keywords: Imetit dihydrobromide, supplier, H3, H4, agonists, Receptors, Histamine, histaminergic, Histamine, H3, Receptors, Tocris Bioscience

2 Citations for Imetit dihydrobromide

Citations are publications that use Tocris products. Selected citations for Imetit dihydrobromide include:

Hashikawa-Hobara et al (2012) Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. Evid Based Complement Alternat Med 340 185 PMID: 22011436

Yoshimoto et al (2006) Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A 103 13866 PMID: 16954192


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