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Ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 323.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.46 mL||77.31 mL||154.63 mL|
|1 mM||3.09 mL||15.46 mL||30.93 mL|
|2 mM||1.55 mL||7.73 mL||15.46 mL|
|10 mM||0.31 mL||1.55 mL||3.09 mL|
References are publications that support the biological activity of the product.
Bersuker et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575 688 PMID: 31634900
If you know of a relevant reference for iFSP1, please let us know.
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Keywords: iFSP1, iFSP1 supplier, ferroptosis, suppressor, protein, 1, FSP1, inhibitors, inhibits, apoptosis, inducing, factor, mitochondria-associated, 2, AIFM2, Other, Reductase, Ferroptosis, 7162, Tocris Bioscience
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