iFSP1

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Cat.No. 7162 - iFSP1 | C20H13N5 | CAS No. 150651-39-1
Description: Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
Chemical Name: 1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.

Technical Data

M. Wt 323.36
Formula C20H13N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 150651-39-1
PubChem ID 699043
InChI Key FNESYDFRCQEEKA-UHFFFAOYSA-N
Smiles CC1=CC=C(C2=C(C#N)C3=NC4=CC=CC=C4N3C(N)=C2C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.47 20

Preparing Stock Solutions

The following data is based on the product molecular weight 323.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.46 mL 77.31 mL 154.63 mL
1 mM 3.09 mL 15.46 mL 30.93 mL
2 mM 1.55 mL 7.73 mL 15.46 mL
10 mM 0.31 mL 1.55 mL 3.09 mL

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References

References are publications that support the biological activity of the product.

Bersuker et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575 688 PMID: 31634900


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Citations for iFSP1

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