Pricing Availability   Qty
Description: Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
Chemical Name: 1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Purity: ≥98% (HPLC)

Biological Activity for iFSP1

iFSP1 is a ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.

Technical Data for iFSP1

M. Wt 323.36
Formula C20H13N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 150651-39-1
PubChem ID 699043
Smiles CC1=CC=C(C2=C(C#N)C3=NC4=CC=CC=C4N3C(N)=C2C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for iFSP1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.47 20

Preparing Stock Solutions for iFSP1

The following data is based on the product molecular weight 323.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.46 mL 77.31 mL 154.63 mL
1 mM 3.09 mL 15.46 mL 30.93 mL
2 mM 1.55 mL 7.73 mL 15.46 mL
10 mM 0.31 mL 1.55 mL 3.09 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for iFSP1

References are publications that support the biological activity of the product.

Bersuker et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575 688 PMID: 31634900

If you know of a relevant reference for iFSP1, please let us know.

View Related Products by Product Action

View all Other Reductase Activators

Keywords: iFSP1, iFSP1 supplier, ferroptosis, suppressor, protein, 1, FSP1, inhibitors, inhibits, apoptosis, inducing, factor, mitochondria-associated, 2, AIFM2, Other, Reductase, Ferroptosis, 7162, Tocris Bioscience

Citations for iFSP1

Citations are publications that use Tocris products.

Currently there are no citations for iFSP1. Do you know of a great paper that uses iFSP1 from Tocris? Please let us know.

Reviews for iFSP1

There are currently no reviews for this product. Be the first to review iFSP1 and earn rewards!

Have you used iFSP1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review