IEM 1925 dihydrobromide

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Description: Voltage- and use-dependent open-channel AMPA blocker
Chemical Name: N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (5)

Biological Activity for IEM 1925 dihydrobromide

IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (KD for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Technical Data for IEM 1925 dihydrobromide

M. Wt 422.24
Formula C17H28N2.2HBr
Storage Desiccate at RT
Purity ≥95% (HPLC)
CAS Number 258282-23-4
PubChem ID 44561101
InChI Key ZCYUSVRXEKAQSL-UHFFFAOYSA-N
Smiles NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IEM 1925 dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 42.22 100
DMSO 21.11 50

Preparing Stock Solutions for IEM 1925 dihydrobromide

The following data is based on the product molecular weight 422.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets for IEM 1925 dihydrobromide

References for IEM 1925 dihydrobromide

References are publications that support the biological activity of the product.

Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232

Kopach et al (2016) Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front.Cell Neurosci. 10 PMID: 26973464


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Keywords: IEM 1925 dihydrobromide, IEM 1925 dihydrobromide supplier, IEM1925, 2HBr, AMPAR, antagonist, blocks, AMPA, receptor, voltage-dependent, channel, blocker, Receptors, 4198, Tocris Bioscience

2 Citations for IEM 1925 dihydrobromide

Citations are publications that use Tocris products. Selected citations for IEM 1925 dihydrobromide include:

Terunaga et al (2023) Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nat Commun 14 1659 PMID: 36966141

Ondrej et al (2021) Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature 594 454-458 PMID: 34079129


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Literature in this Area

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