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Submit ReviewIEM 1925 dihydrobromide
Description: Voltage- and use-dependent open-channel AMPA blocker
Chemical Name: N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
Purity: ≥95% (HPLC)
Biological Activity for IEM 1925 dihydrobromide
IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (KD for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.
Technical Data for IEM 1925 dihydrobromide
| M. Wt | 422.24 |
| Formula | C17H28N2.2HBr |
| Storage | Desiccate at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 258282-23-4 |
| PubChem ID | 44561101 |
| InChI Key | ZCYUSVRXEKAQSL-UHFFFAOYSA-N |
| Smiles | NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for IEM 1925 dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 42.22 | 100 | |
| DMSO | 21.11 | 50 |
Preparing Stock Solutions for IEM 1925 dihydrobromide
The following data is based on the product molecular weight 422.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.68 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for IEM 1925 dihydrobromide
References for IEM 1925 dihydrobromide
References are publications that support the biological activity of the product.
Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232
Kopach et al (2016) Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front.Cell Neurosci. 10 PMID: 26973464
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Keywords: IEM 1925 dihydrobromide, IEM 1925 dihydrobromide supplier, IEM1925, 2HBr, AMPAR, antagonist, blocks, AMPA, receptor, voltage-dependent, channel, blocker, Receptors, 4198, Tocris Bioscience
2 Citations for IEM 1925 dihydrobromide
Citations are publications that use Tocris products. Selected citations for IEM 1925 dihydrobromide include:
Terunaga et al (2023) Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nat Commun 14 1659 PMID: 36966141
Ondrej et al (2021) Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature 594 454-458 PMID: 34079129
Do you know of a great paper that uses IEM 1925 dihydrobromide from Tocris? Please let us know.
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