IEM 1925 dihydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 4198 - IEM 1925 dihydrobromide | C17H28N2.2HBr | CAS No. 258282-23-4
Description: Voltage- and use-dependent open-channel antagonist of AMPA receptors
Chemical Name: N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking receptors more potently than GluR2-containing receptors (KD for GluR2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 (Cat. No. 4199) due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Technical Data

M. Wt 422.24
Formula C17H28N2.2HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 258282-23-4
PubChem ID 44561101
InChI Key ZCYUSVRXEKAQSL-UHFFFAOYSA-N
Smiles NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.11 50
water 42.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 422.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232

Kopach et al (2016) Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front.Cell Neurosci. 10 PMID: 26973464


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