Idebenone

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Cat.No. 3002 - Idebenone | C19H30O5 | CAS No. 58186-27-9
Description: Antioxidant and neuroprotective agent
Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.

Technical Data

M. Wt 338.44
Formula C19H30O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 58186-27-9
PubChem ID 3686
InChI Key JGPMMRGNQUBGND-UHFFFAOYSA-N
Smiles O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.84 100
ethanol 33.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 338.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.77 mL 29.55 mL
5 mM 0.59 mL 2.95 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch.Gerontol.Geriatr. 11 177 PMID: 15374467

Civenni et al (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur.J.Pharmacol. 370 161 PMID: 10323265

Takuma et al (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur.J.Pharmacol. 406 333 PMID: 11040339


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Keywords: Idebenone, supplier, Antioxidant, neuroprotective, agent, Antioxidants, Antioxidants, Tocris Bioscience

Citations for Idebenone

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Idebenone

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