Idebenone

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Cat.No. 3002 - Idebenone | C19H30O5 | CAS No. 58186-27-9
Description: Antioxidant and neuroprotective agent
Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Idebenone

Idebenone is an antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.

Technical Data for Idebenone

M. Wt 338.44
Formula C19H30O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 58186-27-9
PubChem ID 3686
InChI Key JGPMMRGNQUBGND-UHFFFAOYSA-N
Smiles O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Idebenone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.84 100
ethanol 33.84 100

Preparing Stock Solutions for Idebenone

The following data is based on the product molecular weight 338.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.77 mL 29.55 mL
5 mM 0.59 mL 2.95 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for Idebenone

References are publications that support the biological activity of the product.

Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch.Gerontol.Geriatr. 11 177 PMID: 15374467

Civenni et al (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur.J.Pharmacol. 370 161 PMID: 10323265

Takuma et al (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur.J.Pharmacol. 406 333 PMID: 11040339


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Keywords: Idebenone, Idebenone supplier, Antioxidant, neuroprotective, agent, Antioxidants, Ferroptosis, 3002, Tocris Bioscience

1 Citation for Idebenone

Citations are publications that use Tocris products. Selected citations for Idebenone include:

Liu et al (2014) Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal 21 1571 PMID: 24328731


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