ICI 89406

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Cat.No. 0832 - ICI 89406 | C19H22N4O3 | CAS No. 53671-71-9
Description: β antagonist
Chemical Name: N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-N'-phenylurea
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

β-adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 354.41
Formula C19H22N4O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53671-71-9
PubChem ID 123686
InChI Key HTLWRKRZKFAAAH-UHFFFAOYSA-N
Smiles OC(CNCCNC(=O)NC1=CC=CC=C1)COC1=C(C=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in ethanol and to 100 mM in DMSO

References

References are publications that support the biological activity of the product.

Mai (1990) β-Adrenergic Receptors. Comprehensive Medicinal Chemistry. Ed. Hansch. 3 187


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2 Citations for ICI 89406

Citations are publications that use Tocris products. Selected citations for ICI 89406 include:

Mistry et al (2013) Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J Med Chem 56 3852 PMID: 23614528

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350 PMID: 19144685


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