ICI 89406

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Cat.No. 0832 - ICI 89406 | C19H22N4O3 | CAS No. 53671-71-9
Description: β antagonist
Chemical Name: N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-N'-phenylurea
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

β-adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 354.41
Formula C19H22N4O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53671-71-9
PubChem ID 123686
InChI Key HTLWRKRZKFAAAH-UHFFFAOYSA-N
Smiles OC(CNCCNC(=O)NC1=CC=CC=C1)COC1=C(C=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100
ethanol 0

Preparing Stock Solutions

The following data is based on the product molecular weight 354.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mai (1990) β-Adrenergic Receptors. Comprehensive Medicinal Chemistry. Ed. Hansch. 3 187 PMID:


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2 Citations for ICI 89406

Citations are publications that use Tocris products. Selected citations for ICI 89406 include:

Mistry et al (2013) Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J Med Chem 56 3852 PMID: 23614528

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350 PMID: 19144685


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