ICI 63197

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Cat.No. 1816 - ICI 63197 | C9H13N5O | CAS No. 27277-00-5
Description: PDE4 inhibitor
Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.

Compound Libraries

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Technical Data

M. Wt 207.23
Formula C9H13N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 27277-00-5
PubChem ID 62824
InChI Key UQDVRVNMIJAGRK-UHFFFAOYSA-N
Smiles CCCN1C2=NC(N)=NN2C=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 100
ethanol 20.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 207.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.26 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kaulen et al (1989) Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain Res. 503 229 PMID: 2557965

Wachtel (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22 267 PMID: 6302550

Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram J.Pharmacol.Exp.Ther. 305 565 PMID: 12704225


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Keywords: ICI 63197, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, ICI63197, Phosphodiesterases, Tocris Bioscience

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