ICI 63197

Discontinued Product

ICI 63197 (Cat. No. 1816) has been withdrawn from sale for commercial reasons.
Description: PDE4 inhibitor
Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
Purity: ≥99% (HPLC)

Biological Activity for ICI 63197

Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.

Technical Data for ICI 63197

M. Wt 207.23
Formula C9H13N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 27277-00-5
PubChem ID 62824
Smiles CCCN1C2=NC(N)=NN2C=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ICI 63197

Certificate of Analysis / Product Datasheet
Select another batch:

References for ICI 63197

References are publications that support the biological activity of the product.

Kaulen et al (1989) Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain Res. 503 229 PMID: 2557965

Wachtel (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22 267 PMID: 6302550

Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram J.Pharmacol.Exp.Ther. 305 565 PMID: 12704225

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: ICI 63197, ICI 63197 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, ICI63197, 1816, Tocris Bioscience

Citations for ICI 63197

Citations are publications that use Tocris products.

Currently there are no citations for ICI 63197.

Reviews for ICI 63197

There are currently no reviews for this product. Be the first to review ICI 63197 and earn rewards!

Have you used ICI 63197?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review