Discontinued ProductUnfortunately ICI 216,140 (Cat. No. 0823) has been withdrawn from sale for commercial reasons.
Potent antagonist of bombesin/gastrin releasing peptide.
Sold with the permission of AstraZeneca UK Ltd.
|Sequence||HWAVAHL (Modications: His-1 = N-Isobutyryl, Ala-5 = D-Ala, Leu-7 = Leu-NHMe)|
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 916.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.09 mL||5.46 mL||10.92 mL|
|5 mM||0.22 mL||1.09 mL||2.18 mL|
|10 mM||0.11 mL||0.55 mL||1.09 mL|
|50 mM||0.02 mL||0.11 mL||0.22 mL|
References are publications that support the products' biological activity.
Camble et al (1989) N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216,140) a potent in vivo antagonist analog of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 45 1521 PMID: 2555638
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