ICI 216,140

Discontinued Product

ICI 216,140 (Cat. No. 0823) has been withdrawn from sale for commercial reasons.
Description: Potent Bombesin/Gastrin releasing peptide antagonist
Literature (1)

Biological Activity for ICI 216,140

Potent antagonist of bombesin/gastrin releasing peptide.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for ICI 216,140

M. Wt 916.09
Formula C45H65N13O8
Sequence HWAVAHL (Modications: His-1 = N-Isobutyryl, Ala-5 = D-Ala, Leu-7 = Leu-NHMe)

Storage Desiccate at -20°C
CAS Number 124001-41-8
Smiles O=C(NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C(C)C)Cc1cncn1)Cc3c2ccccc2nc3)C)C(C)C)C)Cc4cncn4)[C@@H](NC)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ICI 216,140

Certificate of Analysis / Product Datasheet
Select another batch:

References for ICI 216,140

References are publications that support the biological activity of the product.

Camble et al (1989) N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216,140) a potent in vivo antagonist analog of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 45 1521 PMID: 2555638

Camble et al (1989) ICI-216,140 and other potent in vivo antagonist analogs of bombesin/gastrin releasing peptide. Pept.Chem.,Struct.Biol.,Proc.Am.Pept.Symp.11th mee 174

View Related Products by Product Action

View all Bombesin Receptor Antagonists

Keywords: ICI 216,140, ICI 216,140 supplier, Potent, Bombesin/Gastrin, releasing, peptide, antagonists, GRP-Preferring, Receptors, BB1BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, ICI216140, AstraZeneca, 0823, Tocris Bioscience

Citations for ICI 216,140

Citations are publications that use Tocris products.

Currently there are no citations for ICI 216,140.

Reviews for ICI 216,140

There are currently no reviews for this product. Be the first to review ICI 216,140 and earn rewards!

Have you used ICI 216,140?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.