ICI 216,140

Discontinued Product

ICI 216,140 (Cat. No. 0823) has been withdrawn from sale for commercial reasons.
Cat.No. 0823 - ICI 216,140 | N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe | CAS No. 124001-41-8
Description: Potent Bombesin/Gastrin releasing peptide antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent antagonist of bombesin/gastrin releasing peptide.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 916.09
Formula C45H65N13O8
Sequence HWAVAHL (Modications: His-1 = N-Isobutyryl, Ala-5 = D-Ala, Leu-7 = Leu-NHMe)

Storage Desiccate at -20°C
CAS Number 124001-41-8
Smiles O=C(NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C(C)C)Cc1cncn1)Cc3c2ccccc2nc3)C)C(C)C)C)Cc4cncn4)[C@@H](NC)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Camble et al (1989) N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216,140) a potent in vivo antagonist analog of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 45 1521 PMID: 2555638

Camble et al (1989) ICI-216,140 and other potent in vivo antagonist analogs of bombesin/gastrin releasing peptide. Pept.Chem.,Struct.Biol.,Proc.Am.Pept.Symp.11th mee 174

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Citations for ICI 216,140

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