ICI 216,140

Discontinued Product

Unfortunately ICI 216,140 (Cat. No. 0823) has been withdrawn from sale for commercial reasons.
Cat.No. 0823 - ICI 216,140 | N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe | CAS No. 124001-41-8
Description: Potent Bombesin/Gastrin releasing peptide antagonist
Datasheet
Citations
Literature

Biological Activity

Potent antagonist of bombesin/gastrin releasing peptide.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 916.09
Formula C45H65N13O8
Sequence HWAVAHL (Modications: His-1 = N-Isobutyryl, Ala-5 = D-Ala, Leu-7 = Leu-NHMe)

Storage Desiccate at -20°C
CAS Number 124001-41-8
Smiles O=C(NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C(C)C)Cc1cncn1)Cc3c2ccccc2nc3)C)C(C)C)C)Cc4cncn4)[C@@H](NC)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 916.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.22 mL 1.09 mL 2.18 mL
10 mM 0.11 mL 0.55 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Camble et al (1989) N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216,140) a potent in vivo antagonist analog of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 45 1521 PMID: 2555638

Camble et al (1989) ICI-216,140 and other potent in vivo antagonist analogs of bombesin/gastrin releasing peptide. Pept.Chem.,Struct.Biol.,Proc.Am.Pept.Symp.11th mee 174 PMID:

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Citations for ICI 216,140

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