Discontinued ProductICI 216,140 (Cat. No. 0823) has been withdrawn from sale for commercial reasons.
Potent antagonist of bombesin/gastrin releasing peptide.
Sold with the permission of AstraZeneca UK Ltd.
|Sequence||HWAVAHL (Modications: His-1 = N-Isobutyryl, Ala-5 = D-Ala, Leu-7 = Leu-NHMe)|
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Camble et al (1989) N-Isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216,140) a potent in vivo antagonist analog of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 45 1521 PMID: 2555638
Camble et al (1989) ICI-216,140 and other potent in vivo antagonist analogs of bombesin/gastrin releasing peptide. Pept.Chem.,Struct.Biol.,Proc.Am.Pept.Symp.11th mee 174
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Keywords: ICI 216,140, ICI 216,140 supplier, Potent, Bombesin/Gastrin, releasing, peptide, antagonists, GRP-Preferring, Receptors, BB1BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, ICI216140, AstraZeneca, 0823, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.