ICI 192,605

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Cat.No. 0837 - ICI 192,605 | C22H23ClO5 | CAS No. 117621-64-4
Description: Potent thromboxane A2/TP receptor antagonist
Chemical Name: 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

ICI 192,605 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 402.87
Formula C22H23ClO5
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 117621-64-4
PubChem ID 6604763
InChI Key WHUIENZXNGAHQI-GKZDNZBASA-N
Smiles OC(=O)CC\C=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.29 100
ethanol 40.29 100

Preparing Stock Solutions

The following data is based on the product molecular weight 402.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.41 mL 24.82 mL
5 mM 0.5 mL 2.48 mL 4.96 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Arakawa et al (1993) Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor. Br.J.Pharmacol. 110 127 PMID: 8220872

Brewster et al (1988) The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605. Prostaglandins 36 173 PMID: 2973084

Cao et al (2004) Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur.J.Pharmacol. 485 317 PMID: 14757156


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Keywords: ICI 192,605, supplier, Potent, thromboxane, A2, TXA2, TP, receptor, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI192605, AstraZeneca, Prostanoid, Receptors, Tocris Bioscience

1 Citation for ICI 192,605

Citations are publications that use Tocris products. Selected citations for ICI 192,605 include:

Daray et al (2003) Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein. Naunyn Schmiedebergs Arch Pharmacol 139 1409 PMID: 12922927


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