ICI 162,846

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Cat.No. 0833 - ICI 162,846 | C11H17F3N6O | CAS No. 84545-30-2
Description: Potent H2 antagonist, active in vivo
Chemical Name: N-[1-(4-Carboxamidobutyl)-1H-pyrazol-3-yl)]-N'-(2,2,2-trifluoroethyl)guanidine
Datasheet
Citations
Literature

Biological Activity

A potent histamine H2 receptor antagonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 306.29
Formula C11H17F3N6O
Storage Store at RT
CAS Number 84545-30-2
PubChem ID 134778
InChI Key ALCSGJCIESECFD-UHFFFAOYSA-N
Smiles NC(=O)CCCCN1C=CC(=N1)\N=C(/N)NCC(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.63 100
ethanol 0

Preparing Stock Solutions

The following data is based on the product molecular weight 306.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.65 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gompertz et al (1991) Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions 33 161 PMID: 1716826

Streett et al (1988) Morphological stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicol.Pathol. 16 299 PMID: 2903545

Wilson et al (1986) Inhibition of human gastric secretion by ICI 162,846 - a new histamine H2 receptor antagonist. Br.J.Clin.Pharmacol. 21 685 PMID: 2874823


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Keywords: ICI 162,846, supplier, Potent, H2, antagonists, active, vivo, Receptors, Histamine, histaminergic, ICI162846, AstraZeneca, Histamine, H2, Receptors, Tocris Bioscience

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