A potent histamine H2 receptor antagonist.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 306.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.26 mL||16.32 mL||32.65 mL|
|5 mM||0.65 mL||3.26 mL||6.53 mL|
|10 mM||0.33 mL||1.63 mL||3.26 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the products' biological activity.
Gompertz et al (1991) Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions 33 161 PMID: 1716826
Streett et al (1988) Morphological stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicol.Pathol. 16 299 PMID: 2903545
Wilson et al (1986) Inhibition of human gastric secretion by ICI 162,846 - a new histamine H2 receptor antagonist. Br.J.Clin.Pharmacol. 21 685 PMID: 2874823
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Keywords: ICI 162,846, supplier, Potent, H2, antagonists, active, vivo, Receptors, Histamine, histaminergic, ICI162846, AstraZeneca, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience
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