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Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 442.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.26 mL||11.3 mL||22.59 mL|
|5 mM||0.45 mL||2.26 mL||4.52 mL|
|10 mM||0.23 mL||1.13 mL||2.26 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References are publications that support the biological activity of the product.
Merck Index 12 4927
Murray (1998) Ibutilide. Circulation 97 493 PMID: 9490245
Perry et al (2004) Structural determinants of HERG channel block by clofilium and ibut. Mol.Pharmacol. 66 240 PMID: 15266014
Lee and Lee (1998) Ionic mechanism of ibut. in human atrium: evidence for a drug-induced Na+ current through nifed. inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9 PMID: 9655836
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Keywords: Ibutilide hemifumarate, Ibutilide hemifumarate supplier, antiarrhythmics, ion, channel, blockers, IKr, HERG, L-type, Ca2+, channels, atrial, fibrillation, flutter, Other, Channel, Modulators, 3908, Tocris Bioscience
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