Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 442.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.26 mL||11.3 mL||22.59 mL|
|5 mM||0.45 mL||2.26 mL||4.52 mL|
|10 mM||0.23 mL||1.13 mL||2.26 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References are publications that support the products' biological activity.
Murray (1998) Ibutilide. Circulation 97 493 PMID: 9490245
Perry et al (2004) Structural determinants of HERG channel block by clofilium and ibutilide. Mol.Pharmacol. 66 240 PMID: 15266014
Lee and Lee (1998) Ionic mechanism of ibutilide in human atrium: evidence for a drug-induced Na+ current through nifedipine inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9 PMID: 9655836
If you know of a relevant reference for Ibutilide hemifumarate, please let us know.
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Keywords: Ibutilide hemifumarate, supplier, antiarrhythmics, ion, channel, blockers, IKr, HERG, L-type, Ca2+, channels, atrial, fibrillation, flutter, Other, Channel, Modulators, Other, Channel, Modulators, Tocris Bioscience
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