Ibutilide hemifumarate

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Cat.No. 3908 - Ibutilide hemifumarate | C20H36N2O3S.0.5C4H4O4 | CAS No. 122647-32-9
Description: Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic
Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

Compound Libraries

Ibutilide hemifumarate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 442.61
Formula C20H36N2O3S.½C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 122647-32-9
PubChem ID 5281065
InChI Key PCIOHQNIRPWFMV-WXXKFALUSA-N
Smiles CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1.O=C(/C=C/C(O)=O)O.CCCCCCCN(CC)CCCC(O)C2=CC=C(NS(C)(=O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.26 100
ethanol 44.26 100
water 44.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 442.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.3 mL 22.59 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Merck Index 12 4927 PMID:

Murray (1998) Ibutilide. Circulation 97 493 PMID: 9490245

Perry et al (2004) Structural determinants of HERG channel block by clofilium and ibutilide. Mol.Pharmacol. 66 240 PMID: 15266014

Lee and Lee (1998) Ionic mechanism of ibutilide in human atrium: evidence for a drug-induced Na+ current through nifedipine inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9 PMID: 9655836


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Keywords: Ibutilide hemifumarate, supplier, antiarrhythmics, ion, channel, blockers, IKr, HERG, L-type, Ca2+, channels, atrial, fibrillation, flutter, Other, Channel, Modulators, Other, Channel, Modulators, Tocris Bioscience

Citations for Ibutilide hemifumarate

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