Ibutilide hemifumarate

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Description: Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic
Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate
Purity: ≥98% (HPLC)

Biological Activity for Ibutilide hemifumarate

Ibutilide hemifumarate is a class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

Compound Libraries for Ibutilide hemifumarate

Ibutilide hemifumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ibutilide hemifumarate

M. Wt 442.61
Formula C20H36N2O3S.½C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 122647-32-9
PubChem ID 5281065

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ibutilide hemifumarate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.26 100
water 44.26 100

Preparing Stock Solutions for Ibutilide hemifumarate

The following data is based on the product molecular weight 442.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.3 mL 22.59 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets for Ibutilide hemifumarate

References for Ibutilide hemifumarate

References are publications that support the biological activity of the product.

Merck Index 12 4927

Murray (1998) Ibutilide. Circulation 97 493 PMID: 9490245

Perry et al (2004) Structural determinants of HERG channel block by clofilium and ibut. Mol.Pharmacol. 66 240 PMID: 15266014

Lee and Lee (1998) Ionic mechanism of ibut. in human atrium: evidence for a drug-induced Na+ current through nifed. inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9 PMID: 9655836

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Keywords: Ibutilide hemifumarate, Ibutilide hemifumarate supplier, antiarrhythmics, ion, channel, blockers, IKr, HERG, L-type, Ca2+, channels, atrial, fibrillation, flutter, Other, Channel, Modulators, 3908, Tocris Bioscience

Citations for Ibutilide hemifumarate

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