IBC 293

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Cat.No. 2469 - IBC 293 | C10H11N3O2 | CAS No. 306935-41-1
Description: Selective agonist for the GPR109B (HM74) receptor. Antilipolytic
Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid
Purity: ≥99% (HPLC)

Biological Activity

Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.

Technical Data

M. Wt 205.22
Formula C10H11N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 306935-41-1
PubChem ID 2736690
Smiles CC(C)N1N=NC2=CC(=CC=C12)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.52 100
ethanol 20.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 205.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.87 mL 24.36 mL 48.73 mL
5 mM 0.97 mL 4.87 mL 9.75 mL
10 mM 0.49 mL 2.44 mL 4.87 mL
50 mM 0.1 mL 0.49 mL 0.97 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Semple et al (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J.Med.Chem. 49 1227 PMID: 16480258

If you know of a relevant reference for IBC 293, please let us know.

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