IBC 293

Discontinued Product

IBC 293 (Cat. No. 2469) has been withdrawn from sale for commercial reasons.
Cat.No. 2469 - IBC 293 | C10H11N3O2 | CAS No. 306935-41-1
Description: Selective agonist for the GPR109B (HM74) receptor. Antilipolytic
Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for IBC 293

IBC 293 is a highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.

Technical Data for IBC 293

M. Wt 205.22
Formula C10H11N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 306935-41-1
PubChem ID 2736690
Smiles CC(C)N1N=NC2=CC(=CC=C12)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for IBC 293

References are publications that support the biological activity of the product.

Semple et al (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J.Med.Chem. 49 1227 PMID: 16480258

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Keywords: IBC 293, IBC 293 supplier, Selective, agonists, GPR109B, HM74, receptors, Antilipolytic, GPR109, Receptors, Nicotinic, Acid, IBC293, Hydroxycarboxylic, 2469, Tocris Bioscience

Citations for IBC 293

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Currently there are no citations for IBC 293.

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Literature in this Area

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