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Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 205.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.87 mL||24.36 mL||48.73 mL|
|5 mM||0.97 mL||4.87 mL||9.75 mL|
|10 mM||0.49 mL||2.44 mL||4.87 mL|
|50 mM||0.1 mL||0.49 mL||0.97 mL|
References are publications that support the biological activity of the product.
Semple et al (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J.Med.Chem. 49 1227 PMID: 16480258
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Keywords: IBC 293, IBC 293 supplier, Selective, agonists, GPR109B, HM74, receptors, Antilipolytic, GPR109, Receptors, Nicotinic, Acid, IBC293, Hydroxycarboxylic, 2469, Tocris Bioscience
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