Hypotaurine

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Description: Non-selective endogenous glycine receptor agonist
Chemical Name: 2-Aminoethylsulfinic acid
Datasheet
Citations (1)
Reviews (1)

Biological Activity for Hypotaurine

Hypotaurine is an endogenous inhibitory amino acid.

Technical Data for Hypotaurine

M. Wt 109.14
Formula C2H7NO2S
Storage Desiccate at RT
CAS Number 300-84-5
PubChem ID 107812
InChI Key VVIUBCNYACGLLV-UHFFFAOYSA-N
Smiles NCCS(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Hypotaurine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for Hypotaurine

The following data is based on the product molecular weight 109.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.16 mL 45.81 mL 91.63 mL
5 mM 1.83 mL 9.16 mL 18.33 mL
10 mM 0.92 mL 4.58 mL 9.16 mL
50 mM 0.18 mL 0.92 mL 1.83 mL

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Product Datasheets for Hypotaurine

Certificate of Analysis / Product Datasheet
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References for Hypotaurine

References are publications that support the biological activity of the product.

Okamoto and Sakai (1981) Inhibitory actions of taurocyamine, hypotaurine, homotaurine, taurine and GABA on spike discharges of purkinje cells, and localization of sensitive sites in guinea pig cerebellar slices. Brain Res. 206 371 PMID: 7214140


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Keywords: Hypotaurine, Hypotaurine supplier, Non-Selective, endogenous, glycine, receptor, agonists, GlyR, Glycine, Receptors, 0208, Tocris Bioscience

1 Citation for Hypotaurine

Citations are publications that use Tocris products. Selected citations for Hypotaurine include:

Kopach et al (2022) Multi-target action of β-alanine protects cerebellar tissue from ischemic damage. Cell Death Dis 13 747 PMID: 36038575


Do you know of a great paper that uses Hypotaurine from Tocris? Please let us know.

Reviews for Hypotaurine

Average Rating: 5 (Based on 1 Review.)

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Action of hypotaurine on glycine receptor.
By Anonymous on 06/21/2023
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum

Hypotaurine was in use to find out the relative power of beta-alanine effect on glycine receptor. Outside-out membrane patches underwent application of hypotaurine and then different concentrations of beta-alanine, as indicated at the figure.

Easily dissolvable.

PMID: 36038575
review image