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Submit ReviewHypotaurine
Description: Non-selective endogenous glycine receptor agonist
Chemical Name: 2-Aminoethylsulfinic acid
Biological Activity for Hypotaurine
Hypotaurine is an endogenous inhibitory amino acid.
Technical Data for Hypotaurine
| M. Wt | 109.14 |
| Formula | C2H7NO2S |
| Storage | Desiccate at RT |
| CAS Number | 300-84-5 |
| PubChem ID | 107812 |
| InChI Key | VVIUBCNYACGLLV-UHFFFAOYSA-N |
| Smiles | NCCS(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Hypotaurine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Hypotaurine
The following data is based on the product molecular weight 109.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.16 mL | 45.81 mL | 91.63 mL |
| 5 mM | 1.83 mL | 9.16 mL | 18.33 mL |
| 10 mM | 0.92 mL | 4.58 mL | 9.16 mL |
| 50 mM | 0.18 mL | 0.92 mL | 1.83 mL |
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Product Datasheets for Hypotaurine
References for Hypotaurine
References are publications that support the biological activity of the product.
Okamoto and Sakai (1981) Inhibitory actions of taurocyamine, hypotaurine, homotaurine, taurine and GABA on spike discharges of purkinje cells, and localization of sensitive sites in guinea pig cerebellar slices. Brain Res. 206 371 PMID: 7214140
If you know of a relevant reference for Hypotaurine, please let us know.
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Keywords: Hypotaurine, Hypotaurine supplier, Non-Selective, endogenous, glycine, receptor, agonists, GlyR, Glycine, Receptors, 0208, Tocris Bioscience
1 Citation for Hypotaurine
Citations are publications that use Tocris products. Selected citations for Hypotaurine include:
Kopach et al (2022) Multi-target action of β-alanine protects cerebellar tissue from ischemic damage. Cell Death Dis 13 747 PMID: 36038575
Do you know of a great paper that uses Hypotaurine from Tocris? Please let us know.
Reviews for Hypotaurine
Average Rating: 5 (Based on 1 Review.)
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Action of hypotaurine on glycine receptor.
By
Anonymous on 06/21/2023
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum
Hypotaurine was in use to find out the relative power of beta-alanine effect on glycine receptor. Outside-out membrane patches underwent application of hypotaurine and then different concentrations of beta-alanine, as indicated at the figure.
Easily dissolvable.
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