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Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC50 = 7.5 μM) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||5.04||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 504.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.96 mL||19.82 mL||39.65 mL|
|2.5 mM||0.79 mL||3.96 mL||7.93 mL|
|5 mM||0.4 mL||1.98 mL||3.96 mL|
|25 mM||0.08 mL||0.4 mL||0.79 mL|
References are publications that support the biological activity of the product.
Agostinis et al (2002) Hypericin in cancer treatment: more light on the way. Int.J.Biochem.Cell Biol. 34 221 PMID: 11849990
Hwang et al (2001) Inhibition of c-erbB-2 expression and activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 21 2649 PMID: 11724334
Lenard et al (1993) Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc.Natl.Acad.Sci.U.S.A. 90 158 PMID: 7678335
If you know of a relevant reference for Hypericin, please let us know.
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Keywords: Hypericin, Hypericin supplier, inhibitors, inhibits, tyrosine, kinases, Protein, Kinase, Broad, Spectrum, Inhibitors, Antivirals, Non-selective, 1520, Tocris Bioscience
1 Citation for Hypericin
Citations are publications that use Tocris products. Selected citations for Hypericin include:
Chen et al (2018) Concomitant SK current activation and sodium current inhibition cause J wave syndrome. JCI Insight 3 PMID: 30429367
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Literature in this Area
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