Hypericin

Pricing Availability Delivery Time Qty
Cat.No. 1520 - Hypericin | C30H16O8 | CAS No. 548-04-9
Description: Inhibits tyrosine kinases
Chemical Name: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC50 = 7.5 μM) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

Technical Data

M. Wt 504.45
Formula C30H16O8
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 548-04-9
PubChem ID 5281051
InChI Key BTXNYTINYBABQR-UHFFFAOYSA-N
Smiles OC1=C(C5=C(O)C=C(O)C4=C56)C(C(C(C(C7=C(C)C=C8O)=C(C)C=C3O)=C3C2=O)=C6C7=C8C4=O)=C2C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.22 50
ethanol 5.04 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 504.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Agostinis et al (2002) Hypericin in cancer treatment: more light on the way. Int.J.Biochem.Cell Biol. 34 221 PMID: 11849990

Hwang et al (2001) Inhibition of c-erbB-2 expression and activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 21 2649 PMID: 11724334

Lenard et al (1993) Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc.Natl.Acad.Sci.U.S.A. 90 158 PMID: 7678335


If you know of a relevant reference for Hypericin, please let us know.

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Keywords: inhibitors inhibits tyrosine kinases Protein Kinase Broad Spectrum Broad Spectrum Protein Kinase Inhibitors

Citations for Hypericin

Citations are publications that use Tocris products.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for Hypericin

Protocols

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