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Biological Activity for HTMT dimaleate
HTMT dimaleate is a H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
Technical Data for HTMT dimaleate
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HTMT dimaleate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for HTMT dimaleate
The following data is based on the product molecular weight 614.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.14 mL||16.27 mL|
|5 mM||0.33 mL||1.63 mL||3.25 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References for HTMT dimaleate
References are publications that support the biological activity of the product.
Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308 PMID: 3011908
Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115 PMID: 2959777
Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9
If you know of a relevant reference for HTMT dimaleate, please let us know.
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Keywords: HTMT dimaleate, HTMT dimaleate supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, trifluoromethyl, toluidide, 0646, Tocris Bioscience
2 Citations for HTMT dimaleate
Citations are publications that use Tocris products. Selected citations for HTMT dimaleate include:
Tripathi et al (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J 18 411 PMID: 23961154
Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol 30 582 PMID: 21139565
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Literature in this Area
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