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HTMT dimaleate is a H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 614.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.14 mL||16.27 mL|
|5 mM||0.33 mL||1.63 mL||3.25 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References are publications that support the biological activity of the product.
Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308 PMID: 3011908
Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115 PMID: 2959777
Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9
If you know of a relevant reference for HTMT dimaleate, please let us know.
Keywords: HTMT dimaleate, HTMT dimaleate supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, trifluoromethyl, toluidide, 0646, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for HTMT dimaleate include:
Tripathi et al (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J 18 411 PMID: 23961154
Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol 30 582 PMID: 21139565
Do you know of a great paper that uses HTMT dimaleate from Tocris? Please let us know.
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