HTMT dimaleate

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Cat.No. 0646 - HTMT dimaleate | C19H25F3N4O.2C4H4O4 | CAS No. 195867-54-0
Description: H1/ H2 agonist
Alternative Names: Histamine trifluoromethyl toluidide
Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.

Technical Data

M. Wt 614.57
Formula C19H25F3N4O.2C4H4O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 195867-54-0
PubChem ID 45073433
Smiles [H]OC(=O)\C=C/C(=O)O[H].[H]OC(=O)\C=C/C(=O)O[H].CC(CCCCC(=O)NC1=CC=C(C=C1)C(F)(F)F)NCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 61.46 100
water 61.46 100

Preparing Stock Solutions

The following data is based on the product molecular weight 614.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.14 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308 PMID: 3011908

Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115 PMID: 2959777

Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9 PMID:

If you know of a relevant reference for HTMT dimaleate, please let us know.

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View all Histamine H1 Receptor Agonists

Keywords: HTMT dimaleate, supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, Histamine, trifluoromethyl, toluidide, Histamine, H1, Receptors, Histamine, H2, Receptors, Histamine, H1, Receptors, Tocris Bioscience

2 Citations for HTMT dimaleate

Citations are publications that use Tocris products. Selected citations for HTMT dimaleate include:

Tripathi et al (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J 18 411 PMID: 23961154

Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol 30 582 PMID: 21139565

Do you know of a great paper that uses HTMT dimaleate from Tocris? If so please let us know.

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