HS 38

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Cat.No. 5768 - HS 38 | C14H12ClN5O2S | CAS No. 1030203-81-6
Description: ATP-competitive inhibitor of DAPK and ZIPK
Chemical Name: 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). Also inhibits PIM3 kinase (IC50 = 200 nM) but exhibits no significant effect on Src or Abl kinases. Reduces phosphorylation of regulatory myosin light chain and myosin light chain phosphatase in mouse aortic and rabbit ileal tissues.

Technical Data

M. Wt 349.8
Formula C14H12CIN5O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1030203-81-6
PubChem ID 42938883
InChI Key BDVPSWBRXLWRCV-UHFFFAOYSA-N
Smiles O=C1NC(SC(C(N)=O)C)=NC2=C1C=NN2C3=CC=CC(Cl)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.49 50

Preparing Stock Solutions

The following data is based on the product molecular weight 349.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.29 mL 28.59 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

MacDonald et al (2016) A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol.Pharmacol. 89 105 PMID: 26464323

Carlson et al (2013) Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS.Chem.Biol. 8 2715 PMID: 24070067


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Keywords: HS 38, supplier, HS38, ATP-competitive, inhibitors, inhibits, DAPK, ZIPK, PIM3, kinase, regulatory, myosin, light, chain, myosin, llight, chain, phosphatase, DAPK, DAPK, Tocris Bioscience

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Kinases

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