HS 38

Pricing Availability   Qty
Cat.No. 5768 - HS 38 | C14H12ClN5O2S | CAS No. 1030203-81-6
Description: ATP-competitive inhibitor of DAPK and ZIPK
Chemical Name: 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for HS 38

HS 38 is an ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). Also inhibits PIM3 kinase (IC50 = 200 nM) but exhibits no significant effect on Src or Abl kinases. Reduces phosphorylation of regulatory myosin light chain and myosin light chain phosphatase in mouse aortic and rabbit ileal tissues.

Technical Data for HS 38

M. Wt 349.8
Formula C14H12CIN5O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1030203-81-6
PubChem ID 42938883
Smiles O=C1NC(SC(C(N)=O)C)=NC2=C1C=NN2C3=CC=CC(Cl)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HS 38

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.49 50

Preparing Stock Solutions for HS 38

The following data is based on the product molecular weight 349.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.72 mL 28.59 mL 57.18 mL
2.5 mM 1.14 mL 5.72 mL 11.44 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for HS 38

References are publications that support the biological activity of the product.

MacDonald et al (2016) A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol.Pharmacol. 89 105 PMID: 26464323

Carlson et al (2013) Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS.Chem.Biol. 8 2715 PMID: 24070067

If you know of a relevant reference for HS 38, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Death-Associated Protein Kinase Inhibitors

Keywords: HS 38, HS 38 supplier, HS38, ATP-competitive, inhibitors, inhibits, DAPK, ZIPK, PIM3, kinase, regulatory, myosin, light, chain, llight, phosphatase, 5768, Tocris Bioscience

Citations for HS 38

Citations are publications that use Tocris products.

Currently there are no citations for HS 38. Do you know of a great paper that uses HS 38 from Tocris? Please let us know.

Reviews for HS 38

There are currently no reviews for this product. Be the first to review HS 38 and earn rewards!

Have you used HS 38?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases