HQL 79

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Cat.No. 3530 - HQL 79 | C22H27N5O | CAS No. 162641-16-9
Description: Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Chemical Name: 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.

Technical Data

M. Wt 377.48
Formula C22H27N5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 162641-16-9
PubChem ID 6540277
InChI Key TZQGXAHOROZEKN-UHFFFAOYSA-N
Smiles C1(CCCN2CCC(OC(C4=CC=CC=C4)C3=CC=CC=C3)CC2)=NN=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.44 25

Preparing Stock Solutions

The following data is based on the product molecular weight 377.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.49 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Aritake et al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277 PMID: 16547010

Matsushita et al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11 PMID: 9804057

Mohri et al (2006) Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383 PMID: 16624958


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