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Biological Activity for HQL 79
HQL 79 is an orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.
Compound Libraries for HQL 79
Technical Data for HQL 79
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HQL 79
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for HQL 79
The following data is based on the product molecular weight 377.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.6 mL||52.98 mL||105.97 mL|
|1.25 mM||2.12 mL||10.6 mL||21.19 mL|
|2.5 mM||1.06 mL||5.3 mL||10.6 mL|
|12.5 mM||0.21 mL||1.06 mL||2.12 mL|
References for HQL 79
References are publications that support the biological activity of the product.
Aritake et al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277 PMID: 16547010
Matsushita et al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11 PMID: 9804057
Mohri et al (2006) Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383 PMID: 16624958
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Keywords: HQL 79, HQL 79 supplier, HQL79, specific, hematopoietic, prostaglandin, D, synthase, HPGDS, inhibitors, inhibits, antiallergic, anti-inflammatory, Other, Synthases/Synthetases, 3530, Tocris Bioscience
1 Citation for HQL 79
Citations are publications that use Tocris products. Selected citations for HQL 79 include:
Song et al (2018) Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice. J Pharmacol Exp Ther 367 425 PMID: 30305427
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Literature in this Area
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