HQL 79

Pricing Availability   Qty
Description: Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Chemical Name: 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for HQL 79

HQL 79 is an orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.

Compound Libraries for HQL 79

HQL 79 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HQL 79

M. Wt 377.48
Formula C22H27N5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 162641-16-9
PubChem ID 6540277
InChI Key TZQGXAHOROZEKN-UHFFFAOYSA-N
Smiles C1(CCCN2CCC(OC(C4=CC=CC=C4)C3=CC=CC=C3)CC2)=NN=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HQL 79

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.44 25

Preparing Stock Solutions for HQL 79

The following data is based on the product molecular weight 377.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.6 mL 52.98 mL 105.97 mL
1.25 mM 2.12 mL 10.6 mL 21.19 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
12.5 mM 0.21 mL 1.06 mL 2.12 mL

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References for HQL 79

References are publications that support the biological activity of the product.

Aritake et al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277 PMID: 16547010

Matsushita et al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11 PMID: 9804057

Mohri et al (2006) Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383 PMID: 16624958


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Keywords: HQL 79, HQL 79 supplier, HQL79, specific, hematopoietic, prostaglandin, D, synthase, HPGDS, inhibitors, inhibits, antiallergic, anti-inflammatory, Other, Synthases/Synthetases, 3530, Tocris Bioscience

2 Citations for HQL 79

Citations are publications that use Tocris products. Selected citations for HQL 79 include:

Song et al (2018) Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice. J Pharmacol Exp Ther 367 425 PMID: 30305427

Yu et al (2017) Prostaglandin D2 Regulates SOX9 Nuclear Translocation during Gonadal Sex Determination in Tammar Wallaby, Macropus eugenii. Sex Dev 11 143-150 PMID: 28472794


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