HM 50316

Pricing Availability   Qty
Cat.No. 5850 - HM 50316 | C29H23ClN2O3S | CAS No. 1310361-52-4
Description: High affinity FABP4 inhibitor
Chemical Name: 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid
Purity: ≥98% (HPLC)

Biological Activity for HM 50316

HM 50316 is a high affinity FABP4 inhibitor (Ki < 1 nM). Highly selective for FABP4 over FABP3. Inhibits LPS-induced activation of murine macrophages in vitro.

Technical Data for HM 50316

M. Wt 515.02
Formula C29H23ClN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1310361-52-4
PubChem ID 49872404
Smiles CC(OC1=CC=CC(C2=C(C3=NN(C4=CC=C(C=C4)Cl)C(C5=CC=CS5)=C3)C=CC=C2)=C1)(C(O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HM 50316

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.5 100
ethanol 51.5 100

Preparing Stock Solutions for HM 50316

The following data is based on the product molecular weight 515.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.71 mL 19.42 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for HM 50316

References are publications that support the biological activity of the product.

Liu et al (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg.Med.Chem.Lett. 21 2949 PMID: 21481589

If you know of a relevant reference for HM 50316, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Fatty Acid Binding Protein Inhibitors

Keywords: HM 50316, HM 50316 supplier, HM50316, fatty, acid-binding, protein, adipocyte, a-FABP, FABP4, inhibitors, inhibits, high, affinity, Fatty, Acid, Binding, Proteins, 5850, Tocris Bioscience

Citations for HM 50316

Citations are publications that use Tocris products.

Currently there are no citations for HM 50316. Do you know of a great paper that uses HM 50316 from Tocris? Please let us know.

Reviews for HM 50316

There are currently no reviews for this product. Be the first to review HM 50316 and earn rewards!

Have you used HM 50316?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review