HM 50316

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Cat.No. 5850 - HM 50316 | C29H23ClN2O3S | CAS No. 1310361-52-4
Description: High affinity FABP4 inhibitor
Chemical Name: 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity FABP4 inhibitor (Ki < 1 nM). Highly selective for FABP4 over FABP3. Inhibits LPS-induced activation of murine macrophages in vitro.

Technical Data

M. Wt 515.02
Formula C29H23ClN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1310361-52-4
PubChem ID 49872404
InChI Key HOACFVYJBHHSBC-UHFFFAOYSA-N
Smiles CC(OC1=CC=CC(C2=C(C3=NN(C4=CC=C(C=C4)Cl)C(C5=CC=CS5)=C3)C=CC=C2)=C1)(C(O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 51.5 100
DMSO 51.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 515.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.71 mL 19.42 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Liu et al (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg.Med.Chem.Lett. 21 2949 PMID: 21481589


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Citations for HM 50316

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Literature in this Area

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