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Biological Activity for HM 50316
HM 50316 is a high affinity FABP4 inhibitor (Ki < 1 nM). Highly selective for FABP4 over FABP3. Inhibits LPS-induced activation of murine macrophages in vitro.
Technical Data for HM 50316
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HM 50316
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for HM 50316
The following data is based on the product molecular weight 515.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.94 mL||9.71 mL||19.42 mL|
|5 mM||0.39 mL||1.94 mL||3.88 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References for HM 50316
References are publications that support the biological activity of the product.
Liu et al (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg.Med.Chem.Lett. 21 2949 PMID: 21481589
If you know of a relevant reference for HM 50316, please let us know.
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Keywords: HM 50316, HM 50316 supplier, HM50316, fatty, acid-binding, protein, adipocyte, a-FABP, FABP4, inhibitors, inhibits, high, affinity, Fatty, Acid, Binding, Proteins, 5850, Tocris Bioscience
Citations for HM 50316
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