HM 50316

Discontinued Product

HM 50316 (Cat. No. 5850) has been withdrawn from sale for commercial reasons.
Description: High affinity FABP4 inhibitor
Chemical Name: 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid
Purity: ≥98% (HPLC)

Biological Activity for HM 50316

HM 50316 is a high affinity FABP4 inhibitor (Ki < 1 nM). Highly selective for FABP4 over FABP3. Inhibits LPS-induced activation of murine macrophages in vitro.

Technical Data for HM 50316

M. Wt 515.02
Formula C29H23ClN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1310361-52-4
PubChem ID 49872404
Smiles CC(OC1=CC=CC(C2=C(C3=NN(C4=CC=C(C=C4)Cl)C(C5=CC=CS5)=C3)C=CC=C2)=C1)(C(O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for HM 50316

References are publications that support the biological activity of the product.

Liu et al (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg.Med.Chem.Lett. 21 2949 PMID: 21481589

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Keywords: HM 50316, HM 50316 supplier, HM50316, fatty, acid-binding, protein, adipocyte, a-FABP, FABP4, inhibitors, inhibits, high, affinity, Fatty, Acid, Binding, Proteins, 5850, Tocris Bioscience

Citations for HM 50316

Citations are publications that use Tocris products.

Currently there are no citations for HM 50316.

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