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HLM 006474

Cat. No. 5283 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 5283 - HLM 006474 | C25H25N3O2 | CAS No. 353519-63-8
Description: E2F transcription factor inhibitor
Chemical Name: 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

Technical Data

M. Wt 399.48
Formula C25H25N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 353519-63-8
PubChem ID 2895500
InChI Key CYNZBLNMIJNBSF-UHFFFAOYSA-N
Smiles CC1=C(OCC)C=CC(C(C3=C(O)C(N=C(C)C=C4)=C4C=C3)NC2=NC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.99 20

Preparing Stock Solutions

The following data is based on the product molecular weight 399.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.52 mL 62.58 mL 125.16 mL
1 mM 2.5 mL 12.52 mL 25.03 mL
2 mM 1.25 mL 6.26 mL 12.52 mL
10 mM 0.25 mL 1.25 mL 2.5 mL

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References

References are publications that support the biological activity of the product.

Ma et al (2008) A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 68 6292 PMID: 18676853

Conklin et al (2012) The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 3 1244 PMID: 23212373

If you know of a relevant reference for HLM 006474, please let us know.

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1 Citation for HLM 006474

Citations are publications that use Tocris products. Selected citations for HLM 006474 include:

Dong (2018) BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis. Cell Death Dis 9 203 PMID: 29434197

Do you know of a great paper that uses HLM 006474 from Tocris? Please let us know.

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Literature in this Area

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