Insulin-regulated aminopeptidase (IRAP) inhibitor (Ki = 2.01 μM). Improves memory in control and memory-deficient mice models.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||3.12||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 312.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.2 mL||16.01 mL||32.02 mL|
|5 mM||0.64 mL||3.2 mL||6.4 mL|
|10 mM||0.32 mL||1.6 mL||3.2 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the products' biological activity.
Albiston et al (2010) Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase. Mol.Pharmacol. 78 600 PMID: 20628006
If you know of a relevant reference for HFI 142, please let us know.
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Keywords: HFI 142, supplier, HFI, 142, inhibitors, inhibits, insulin-regulated, aminopeptidases, IRAPs, memory, Aminopeptidases, Aminopeptidases, Tocris Bioscience
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