HFI 142

Pricing Availability   Qty
Cat.No. 5627 - HFI 142 | C17H16N2O4 | CAS No. 332164-34-8
Description: Insulin-regulated aminopeptidase (IRAP) inhibitor
Chemical Name: Ethyl 2-amino-7-hydroxy-4-(3-pyridinyl)-4H-1-benzopyran-3-carboxylate
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Insulin-regulated aminopeptidase (IRAP) inhibitor (Ki = 2.01 μM). Improves memory in control and memory-deficient mice models.

Technical Data

M. Wt 312.32
Formula C17H16N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 332164-34-8
PubChem ID 655457
Smiles OC1=CC(OC(N)=C(C(OCC)=O)C2C3=CN=CC=C3)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 312.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Albiston et al (2010) Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of Ins-regulated aminopeptidase. Mol.Pharmacol. 78 600 PMID: 20628006

If you know of a relevant reference for HFI 142, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Aminopeptidase Inhibitors

Keywords: HFI 142, HFI 142 supplier, HFI, 142, inhibitors, inhibits, insulin-regulated, aminopeptidases, IRAPs, memory, Aminopeptidases, 5627, Tocris Bioscience

Citations for HFI 142

Citations are publications that use Tocris products.

Currently there are no citations for HFI 142. Do you know of a great paper that uses HFI 142 from Tocris? Please let us know.

Reviews for HFI 142

There are currently no reviews for this product. Be the first to review HFI 142 and earn rewards!

Have you used HFI 142?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells