HFI 142

Discontinued Product

HFI 142 (Cat. No. 5627) has been withdrawn from sale for commercial reasons.
Cat.No. 5627 - HFI 142 | C17H16N2O4 | CAS No. 332164-34-8
Description: Insulin-regulated aminopeptidase (IRAP) inhibitor
Chemical Name: Ethyl 2-amino-7-hydroxy-4-(3-pyridinyl)-4H-1-benzopyran-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Insulin-regulated aminopeptidase (IRAP) inhibitor (Ki = 2.01 μM). Improves memory in control and memory-deficient mice models.

Technical Data

M. Wt 312.32
Formula C17H16N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 332164-34-8
PubChem ID 655457
InChI Key JOPNHSIHFSZJMB-UHFFFAOYSA-N
Smiles OC1=CC(OC(N)=C(C(OCC)=O)C2C3=CN=CC=C3)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Albiston et al (2010) Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of Ins-regulated aminopeptidase. Mol.Pharmacol. 78 600 PMID: 20628006

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Keywords: HFI 142, HFI 142 supplier, HFI, 142, inhibitors, inhibits, insulin-regulated, aminopeptidases, IRAPs, memory, Aminopeptidases, 5627, Tocris Bioscience

Citations for HFI 142

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