HFI 142

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Cat.No. 5627 - HFI 142 | C17H16N2O4 | CAS No. 332164-34-8
Description: Insulin-regulated aminopeptidase (IRAP) inhibitor
Chemical Name: Ethyl 2-amino-7-hydroxy-4-(3-pyridinyl)-4H-1-benzopyran-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Insulin-regulated aminopeptidase (IRAP) inhibitor (Ki = 2.01 μM). Improves memory in control and memory-deficient mice models.

Compound Libraries

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Technical Data

M. Wt 312.32
Formula C17H16N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 332164-34-8
PubChem ID 655457
InChI Key JOPNHSIHFSZJMB-UHFFFAOYSA-N
Smiles OC1=CC(OC(N)=C(C(OCC)=O)C2C3=CN=CC=C3)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.23 100
ethanol 3.12 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 312.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Albiston et al (2010) Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase. Mol.Pharmacol. 78 600 PMID: 20628006


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