Inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 954.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.05 mL||5.24 mL||10.48 mL|
|5 mM||0.21 mL||1.05 mL||2.1 mL|
|10 mM||0.1 mL||0.52 mL||1.05 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References are publications that support the biological activity of the product.
Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 28 56 PMID: 22886699
Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741 PMID: 10958789
If you know of a relevant reference for Hexa-D-arginine, please let us know.
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Citations for Hexa-D-arginine
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