Pricing Availability   Qty
Description: Furin inhibitor
Purity: ≥95% (HPLC)
Citations (2)

Biological Activity for Hexa-D-arginine

Hexa-D-arginine is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Technical Data for Hexa-D-arginine

M. Wt 954.16
Formula C36H75N25O6
Sequence RRRRRR

(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6 = D-Arg)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 673202-67-0
PubChem ID 57358476

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Hexa-D-arginine

Solubility Soluble to 2 mg/ml in water

Product Datasheets for Hexa-D-arginine

Certificate of Analysis / Product Datasheet
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References for Hexa-D-arginine

References are publications that support the biological activity of the product.

Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 28 56 PMID: 22886699

Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741 PMID: 10958789

Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239

If you know of a relevant reference for Hexa-D-arginine, please let us know.

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Keywords: Hexa-D-arginine, Hexa-D-arginine supplier, Hexa-D-arginine, selective, furin, inhibitors, inhibits, paired, basic, amino, acid, cleaving, enzyme, PACE, subtilisin-like, proprotein, convertases, Furin, 4711, Tocris Bioscience

2 Citations for Hexa-D-arginine

Citations are publications that use Tocris products. Selected citations for Hexa-D-arginine include:

Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. PMID: 33007239

Wang et al (2019) Biowire Model of Interstitial and Focal Cardiac Fibrosis. ACS Cent Sci 5 1146 PMID: 31403068

Do you know of a great paper that uses Hexa-D-arginine from Tocris? Please let us know.

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