Hexa-D-arginine

Pricing Availability Delivery Time Qty
Cat.No. 4711 - Hexa-D-arginine | D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 | CAS No. 673202-67-0
Description: Furin inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Technical Data

M. Wt 954.16
Formula C36H75N25O6
Sequence RRRRRR

(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)

Storage Store at -20°C
CAS Number 673202-67-0
PubChem ID 57358476
InChI Key BMLTZEAFQLJTIZ-TZNXUKFXSA-N
Smiles [H]N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 954.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.24 mL 10.48 mL
5 mM 0.21 mL 1.05 mL 2.1 mL
10 mM 0.1 mL 0.52 mL 1.05 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 28 56 PMID: 22886699

Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741 PMID: 10958789


If you know of a relevant reference for Hexa-D-arginine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: Hexa-D-arginine, supplier, Hexa-D-arginine, selective, furin, inhibitors, inhibits, paired, basic, amino, acid, cleaving, enzyme, PACE, subtilisin-like, proprotein, convertases, Other, Proteases, Other, Proteases, Tocris Bioscience

Citations for Hexa-D-arginine

Citations are publications that use Tocris products.

Currently there are no citations for Hexa-D-arginine. Do you know of a great paper that uses Hexa-D-arginine from Tocris? If so please let us know.

Reviews for Hexa-D-arginine

There are currently no reviews for this product. Be the first to review Hexa-D-arginine and earn rewards!

Have you used Hexa-D-arginine?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells