Hexa-D-arginine

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Cat.No. 4711 - Hexa-D-arginine | D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 | CAS No. 673202-67-0
Description: Furin inhibitor
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Technical Data

M. Wt 954.16
Formula C36H75N25O6
Sequence RRRRRR

(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)

Storage Store at -20°C
CAS Number 673202-67-0
PubChem ID 57358476
InChI Key BMLTZEAFQLJTIZ-TZNXUKFXSA-N
Smiles [H]N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 28 56 PMID: 22886699

Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741 PMID: 10958789


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Keywords: Hexa-D-arginine, Hexa-D-arginine supplier, Hexa-D-arginine, selective, furin, inhibitors, inhibits, paired, basic, amino, acid, cleaving, enzyme, PACE, subtilisin-like, proprotein, convertases, Other, Proteases, 4711, Tocris Bioscience

1 Citation for Hexa-D-arginine

Citations are publications that use Tocris products. Selected citations for Hexa-D-arginine include:

Wang et al (2019) Biowire Model of Interstitial and Focal Cardiac Fibrosis. ACS Cent Sci 5 1146 PMID: 31403068


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Literature in this Area

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