Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
Sold for research use only under patent license from Hybrigenics S.A.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 266.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.75 mL||18.75 mL||37.5 mL|
|5 mM||0.75 mL||3.75 mL||7.5 mL|
|10 mM||0.38 mL||1.88 mL||3.75 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
References are publications that support the biological activity of the product.
Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286 PMID: 19671755
Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552 PMID: 20186914
If you know of a relevant reference for HBX 41108, please let us know.
View Related Products by Product Action
Keywords: HBX 41108, HBX 41108 supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, inhibits, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated, Deubiquitinating, Enzymes, 4285, Tocris Bioscience
Citations for HBX 41108
Citations are publications that use Tocris products.
Currently there are no citations for HBX 41108. Do you know of a great paper that uses HBX 41108 from Tocris? Please let us know.
Reviews for HBX 41108
There are currently no reviews for this product. Be the first to review HBX 41108 and earn rewards!
Have you used HBX 41108?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)New
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells