HBX 41108

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Description: Selective USP7 inhibitor
Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Purity: ≥98% (HPLC)
Citations (6)
Reviews (1)

Biological Activity for HBX 41108

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Licensing Information

Sold for research use only under patent license from Hybrigenics S.A.

Technical Data for HBX 41108

M. Wt 266.64
Formula C13H3ClN4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 924296-39-9
PubChem ID 16065773
Smiles O=C2C1=CC(Cl)=CC=C1C3=C2N=C(C#N)C(C#N)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HBX 41108

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.66 100

Preparing Stock Solutions for HBX 41108

The following data is based on the product molecular weight 266.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.75 mL 37.5 mL
5 mM 0.75 mL 3.75 mL 7.5 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets for HBX 41108

Certificate of Analysis / Product Datasheet
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References for HBX 41108

References are publications that support the biological activity of the product.

Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286 PMID: 19671755

Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552 PMID: 20186914

If you know of a relevant reference for HBX 41108, please let us know.

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Keywords: HBX 41108, HBX 41108 supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, inhibits, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated, Deubiquitinating, Enzymes, 4285, Tocris Bioscience

6 Citations for HBX 41108

Citations are publications that use Tocris products. Selected citations for HBX 41108 include:

Hesham et al (2020) TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts. J Cell Sci PMID: 34005169

Hesham et al (2020) TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts. J Cell Sci 133 PMID: 32434871

Benedikt M et al (2021) ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context. Front Chem 9 640105 PMID: 33718328

Ji et al (2019) USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin. Nat Commun 10 4184 PMID: 31519875

Do you know of a great paper that uses HBX 41108 from Tocris? Please let us know.

Reviews for HBX 41108

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USP7 inhibitors 1 (HBX41108).
By Anonymous on 12/10/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293

HEK293T cells stably expressing the STF-Luc reporter were pretreated with increasing amounts of USP7 inhibitors HBX41108

PMID: 31519875
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