HA 130

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Cat.No. 4196 - HA 130 | C24H19BFNO5S | CAS No. 1229652-21-4
Description: Potent and selective autotaxin inhibitor
Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

Compound Libraries

HA 130 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 463.29
Formula C24H19BFNO5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1229652-21-4
PubChem ID 46911532
InChI Key VTNKMYWFWQTEHE-XKZIYDEJSA-N
Smiles FC1=CC=C(CN3C(/C(SC3=O)=C/C2=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Albers et al (2010) Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 53 4958 PMID: 20536182

Albers et al (2010) Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 107 7257 PMID: 20360563


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View all Autotaxin Inhibitors

Keywords: HA 130, HA 130 supplier, HA130, autotaxin, inhibitors, reversible, reversibly, inhibits, selective, atx, npp2, lysophospholipases, d, lysopld, Autotaxin, 4196, Tocris Bioscience

1 Citation for HA 130

Citations are publications that use Tocris products. Selected citations for HA 130 include:

Wheeler et al (2015) The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. J Neurosci 35 11399 PMID: 26269646


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Literature in this Area

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