HA 130

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Cat.No. 4196 - HA 130 | C24H19BFNO5S | CAS No. 1229652-21-4
Description: Potent and selective autotaxin inhibitor
Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

Compound Libraries

HA 130 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 463.29
Formula C24H19BFNO5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1229652-21-4
PubChem ID 46911532
InChI Key VTNKMYWFWQTEHE-XKZIYDEJSA-N
Smiles FC1=CC=C(CN3C(/C(SC3=O)=C/C2=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Albers et al (2010) Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 53 4958 PMID: 20536182

Albers et al (2010) Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 107 7257 PMID: 20360563


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Keywords: HA130 autotaxin inhibitors reversible reversibly inhibits selective atx npp2 lysophospholipases d lysopld Autotaxin

Citations for HA 130

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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  • Epigenetics in Cancer
  • Receptor Signaling
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  • Angiogenesis
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Pathways for HA 130

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