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Description: PARP14 inhibitor; cell-permeable
Chemical Name: 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for H10
H10 is a PARP14 inhibitor (IC50 = 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cells in vitro.
Technical Data for H10
| M. Wt | 557.58 |
| Formula | C24H27N7O7S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2084811-68-5 |
| PubChem ID | 122707115 |
| InChI Key | MUOMSHSMJCWQFH-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=CC(NC(CCC(NCCC2=CN(N=N2)CCNS(=O)(C3=CC(C(O)=O)=CC=C3)=O)=O)=O)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for H10
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.88 | 50 |
Preparing Stock Solutions for H10
The following data is based on the product molecular weight 557.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.59 mL | 17.93 mL | 35.87 mL |
| 2.5 mM | 0.72 mL | 3.59 mL | 7.17 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.59 mL |
| 25 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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Product Datasheets for H10
References for H10
References are publications that support the biological activity of the product.
Peng et al (2017) Small molecule microarray based discovery of PARP14 inhibitors. Angew.Chem.Int.Ed.Engl. 56 248 PMID: 27918638
If you know of a relevant reference for H10, please let us know.
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Keywords: H10, H10 supplier, PARP14, inhibitors, inhibits, apoptosis, Poly(ADP-ribose), Polymerase, 6228, Tocris Bioscience
Citations for H10
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