H10

Pricing Availability   Qty
Description: PARP14 inhibitor; cell-permeable
Chemical Name: 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for H10

H10 is a PARP14 inhibitor (IC50 = 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cells in vitro.

Technical Data for H10

M. Wt 557.58
Formula C24H27N7O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2084811-68-5
PubChem ID 122707115
InChI Key MUOMSHSMJCWQFH-UHFFFAOYSA-N
Smiles NC(C1=CC=CC(NC(CCC(NCCC2=CN(N=N2)CCNS(=O)(C3=CC(C(O)=O)=CC=C3)=O)=O)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for H10

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.88 50

Preparing Stock Solutions for H10

The following data is based on the product molecular weight 557.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.59 mL 17.93 mL 35.87 mL
2.5 mM 0.72 mL 3.59 mL 7.17 mL
5 mM 0.36 mL 1.79 mL 3.59 mL
25 mM 0.07 mL 0.36 mL 0.72 mL

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References for H10

References are publications that support the biological activity of the product.

Peng et al (2017) Small molecule microarray based discovery of PARP14 inhibitors. Angew.Chem.Int.Ed.Engl. 56 248 PMID: 27918638


If you know of a relevant reference for H10, please let us know.

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Keywords: H10, H10 supplier, PARP14, inhibitors, inhibits, apoptosis, Poly(ADP-ribose), Polymerase, 6228, Tocris Bioscience

1 Citation for H10

Citations are publications that use Tocris products. Selected citations for H10 include:

George-Lucian et al (2022) The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun 13 5063 PMID: 36030235


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Reviews for H10

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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