GYKI 47261 dihydrochloride

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Cat.No. 3099 - GYKI 47261 dihydrochloride | C18H15ClN4.2HCl | CAS No. 1217049-32-5
Description: Non-competitive AMPA antagonist
Chemical Name: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-benzeneamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-competitive AMPA receptor antagonist (IC50 = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.

Technical Data

M. Wt 395.71
Formula C18H15ClN4.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1217049-32-5
PubChem ID 46861544
InChI Key HUNSEMNKAFDVDI-UHFFFAOYSA-N
Smiles ClC1=CC=C3C(C(C4=CC=C(N)C=C4)=NN2C(C3)=NC(C)=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.27 mL
5 mM 0.51 mL 2.53 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Abraham et al (2000) New non competitive AMPA antagonists. Bioorg.Med.Chem. 8 2127 PMID: 11003158

Bibbiani et al (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 196 422 PMID: 16203001

Solyo (2001) Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie 25 S62 PMID:


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Citations for GYKI 47261 dihydrochloride

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