GW 9508

Pricing Availability   Qty
Cat.No. 2649 - GW 9508 | C22H21NO3 | CAS No. 885101-89-3
Description: Potent and selective FFA1 (GPR40) agonist
Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50 = 6.14).

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries

GW 9508 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 347.41
Formula C22H21NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 885101-89-3
PubChem ID 11595431
InChI Key DGENZVKCTGIDRZ-UHFFFAOYSA-N
Smiles OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.74 100
ethanol 34.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Garrido et al (2006) Synthesis and activity of small molecule GPR40 agonists. Bioorg.Med.Chem.Lett. 16 1840 PMID: 16439116

Briscoe et al (2006) Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br.J.Pharmacol. 148 619 PMID: 16702987

Zhao and Chen (2008) Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J.Endocrinol. 198 533 PMID: 18550787


If you know of a relevant reference for GW 9508, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: GW 9508, GW 9508 supplier, Potent, selective, FFA1, GPR40, agonists, Receptors, Free, Fatty, Acid, GW9508, GlaxoSmithKline, GSK, 2649, Tocris Bioscience

3 Citations for GW 9508

Citations are publications that use Tocris products. Selected citations for GW 9508 include:

Dragano (2017) Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation 14 91 PMID: 28446241

Oh et al (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142 687 PMID: 20813258

Watson et al (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol 81 631 PMID: 22282525


Do you know of a great paper that uses GW 9508 from Tocris? Please let us know.

Reviews for GW 9508

There are currently no reviews for this product. Be the first to review GW 9508 and earn rewards!

Have you used GW 9508?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling