GW 791343 hydrochloride
P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 483.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.07 mL||10.33 mL||20.67 mL|
|5 mM||0.41 mL||2.07 mL||4.13 mL|
|10 mM||0.21 mL||1.03 mL||2.07 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
References are publications that support the biological activity of the product.
Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737 PMID: 18071294
Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738 PMID: 18660826
If you know of a relevant reference for GW 791343 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GW 791343 hydrochloride, GW 791343 hydrochloride supplier, P2X7, allosteric, modulators, Receptors, Purinergic, purinoceptors, GW791343, hydrochloride, P2X, 3385, Tocris Bioscience
Citations for GW 791343 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for GW 791343 hydrochloride. Do you know of a great paper that uses GW 791343 hydrochloride from Tocris? Please let us know.
Reviews for GW 791343 hydrochloride
There are currently no reviews for this product. Be the first to review GW 791343 hydrochloride and earn rewards!
Have you used GW 791343 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.