GW 791343 hydrochloride
P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 483.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.07 mL||10.33 mL||20.67 mL|
|5 mM||0.41 mL||2.07 mL||4.13 mL|
|10 mM||0.21 mL||1.03 mL||2.07 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
References are publications that support the products' biological activity.
Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737 PMID: 18071294
Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738 PMID: 18660826
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Keywords: GW 791343 hydrochloride, supplier, P2X7, allosteric, modulators, Receptors, Purinergic, purinoceptors, GW791343, hydrochloride, P2X, Receptors, P2X, Receptors, Tocris Bioscience
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Literature in this Area
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