GW 791343 hydrochloride

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Cat.No. 3385 - GW 791343 hydrochloride | C20H24F2N4O.3HCl | CAS No. 309712-55-8
Description: P2X7 allosteric modulator
Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.

Technical Data

M. Wt 483.81
Formula C20H24F2N4O.3HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 309712-55-8
PubChem ID 9848159
InChI Key WSBRAHWNJBXXJM-UHFFFAOYSA-N
Smiles CC(C=C2)=C(NC(CNC3=CC=C(F)C(F)=C3)=O)C=C2CN1CCNCC1.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.38 100
water 48.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 483.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.33 mL 20.67 mL
5 mM 0.41 mL 2.07 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737 PMID: 18071294

Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738 PMID: 18660826


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