GW 438014A

Discontinued Product

Unfortunately GW 438014A (Cat. No. 4669) has been withdrawn from sale for commercial reasons.
Cat.No. 4669 - GW 438014A | CAS No. 469861-49-2
Description: NPY Y5 receptor antagonist
Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Neuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Compound Libraries

GW 438014A is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 437.51
Formula C22H19N3O.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 469861-49-2
PubChem ID 6918626
InChI Key AVYFZOKRFCFQLP-UHFFFAOYSA-N
Smiles O=C(C4=CC=CC=C4)NC2=NC1=CC=CC=C1N2CCC3=CC=CC=C3.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 437.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.43 mL 22.86 mL
5 mM 0.46 mL 2.29 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul.Pept. 106 47 PMID: 12047910

Benmaamar et al (2005) Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79 PMID: 15582717

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Keywords: GW 438014A, supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, NPY, Receptors, NPY, Receptors, Tocris Bioscience

Citations for GW 438014A

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Currently there are no citations for GW 438014A.

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