GW 438014A

Discontinued Product

GW 438014A (Cat. No. 4669) has been withdrawn from sale for commercial reasons.
Description: NPY Y5 receptor antagonist
Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for GW 438014A

Neuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for GW 438014A

M. Wt 437.51
Formula C22H19N3O.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 469861-49-2
PubChem ID 6918626
Smiles O=C(C4=CC=CC=C4)NC2=NC1=CC=CC=C1N2CCC3=CC=CC=C3.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GW 438014A

References are publications that support the biological activity of the product.

Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul.Pept. 106 47 PMID: 12047910

Benmaamar et al (2005) Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79 PMID: 15582717

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Keywords: GW 438014A, GW 438014A supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, Receptors, 4669, Tocris Bioscience

Citations for GW 438014A

Citations are publications that use Tocris products.

Currently there are no citations for GW 438014A.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.