Discontinued ProductUnfortunately GW 438014A (Cat. No. 4669) has been withdrawn from sale for commercial reasons.
Neuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.
Sold for research purposes under agreement from GlaxoSmithKline.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 437.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.29 mL||11.43 mL||22.86 mL|
|5 mM||0.46 mL||2.29 mL||4.57 mL|
|10 mM||0.23 mL||1.14 mL||2.29 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul.Pept. 106 47 PMID: 12047910
Benmaamar et al (2005) Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79 PMID: 15582717
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Keywords: GW 438014A, supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, NPY, Receptors, Tocris Bioscience
Citations for GW 438014A
Citations are publications that use Tocris products.
Currently there are no citations for GW 438014A.
Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.