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Discontinued ProductGW 438014A (Cat. No. 4669) has been withdrawn from sale for commercial reasons.
Neuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.
Sold for research purposes under agreement from GlaxoSmithKline.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul.Pept. 106 47 PMID: 12047910
Benmaamar et al (2005) Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79 PMID: 15582717
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Keywords: GW 438014A, GW 438014A supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, Receptors, 4669, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.