GW 405833

Pricing Availability Delivery Time Qty
Cat.No. 2374 - GW 405833 | C23H24Cl2N2O3 | CAS No. 180002-83-9
Description: Selective, high affinity CB2 receptor partial agonist
Alternative Names: L-768,242
Chemical Name: 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

Technical Data

M. Wt 447.36
Formula C23H24Cl2N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 180002-83-9
PubChem ID 9911463
InChI Key FSFZRNZSZYDVLI-UHFFFAOYSA-N
Smiles COC1=CC=C2N(C(=O)C3=C(Cl)C(Cl)=CC=C3)C(C)=C(CCN3CCOCC3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.36 50
ethanol 22.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 447.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.18 mL 22.35 mL
5 mM 0.45 mL 2.24 mL 4.47 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Clayton et al (2002) CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain 96 253 PMID: 11972997

Valenzano et al (2005) Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology 48 658 PMID: 15814101


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Keywords: GW 405833, supplier, Selective, high, affinity, CB2, receptor, partial, agonists, cannabinoids, Receptors, GW405833, L768242, cb2r, L-768,242, CB2, Receptors, CB2, Receptors, Tocris Bioscience

2 Citations for GW 405833

Citations are publications that use Tocris products. Selected citations for GW 405833 include:

Marini et al (2013) Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol 169 887 PMID: 23711022

McGuinness et al (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Cardiovasc Res 14 49 PMID: 19171920


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