You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
GTS 21 dihydrochloride
Partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation. Also has anti-inflammatory effects independent of α7 nAChRs.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 381.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.25 mL||26.23 mL||52.45 mL|
|2.5 mM||1.05 mL||5.25 mL||10.49 mL|
|5 mM||0.52 mL||2.62 mL||5.25 mL|
|25 mM||0.1 mL||0.52 mL||1.05 mL|
References are publications that support the biological activity of the product.
Stevens et al (2010) Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain.Res. 1352 140 PMID: 20599427
Meyer et al (1994) Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev.Res. 31 127
Olincy et al (2012) Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb.Exp.Pharmacol. 213 211 PMID: 23027417
Garg and Loring et al (2019) GTS-21 has cell-specific anti-inflammatory effects independent of a7 nicotinic acetylcholine receptors. PLoS One 14 e0214942 PMID: 30947238
If you know of a relevant reference for GTS 21 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: GTS 21 dihydrochloride, GTS 21 dihydrochloride supplier, GTS21, dihydrochloride, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, a4b2, α4, β2, anti, inflammatory, Alzheimer's, disease, DMXBA, alpha7, alpha4beta2, Nicotinic, (a7), Receptors, 4557, Tocris Bioscience
Citations for GTS 21 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for GTS 21 dihydrochloride. Do you know of a great paper that uses GTS 21 dihydrochloride from Tocris? Please let us know.
Reviews for GTS 21 dihydrochloride
There are currently no reviews for this product. Be the first to review GTS 21 dihydrochloride and earn rewards!
Have you used GTS 21 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.