GTS 21 dihydrochloride

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Cat.No. 4557 - GTS 21 dihydrochloride | C19H20N2O2.2HCl | CAS No. 156223-05-1
Description: Partial agonist at α7 nAChR
Alternative Names: DMXBA
Chemical Name: 3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation.

Technical Data

M. Wt 381.3
Formula C19H20N2O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 156223-05-1
PubChem ID 122225
InChI Key BXKYFUGAAFLYJL-UHFFFAOYSA-N
Smiles COC(C=C3OC)=CC=C3\C=C1C(C2=CC=CN=C2)=NCCC/1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 381.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.23 mL
5 mM 0.52 mL 2.62 mL 5.25 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Stevens et al (2010) Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain.Res. 1352 140 PMID: 20599427

Meyer et al (1994) Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev.Res. 31 127 PMID:

Olincy et al (2012) Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb.Exp.Pharmacol. 213 211 PMID: 23027417


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Keywords: GTS21 dihydrochloride partial agonist a7 nAChR nicotinic acetylcholine receptor α7 agonists a4b2 α4 β2 anti inflammatory Alzheimer's disease DMXBA alpha7 alpha4beta2 DMXBA Nicotinic (a7) Receptors

Citations for GTS 21 dihydrochloride

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