GT 949

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Cat.No. 6578 - GT 949 | C30H37N7O2 | CAS No. 460330-27-2
Description: Potent and selective positive allosteric modulator of EAAT2
Chemical Name: 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors.

Technical Data

M. Wt 527.66
Formula C30H37N7O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 460330-27-2
PubChem ID 3195790
InChI Key ZVWPOIUAPXDLMB-UHFFFAOYSA-N
Smiles COC1=CC=C2NC(C(C(C3=NN=NN3CCC4=CC=CC=C4)N5CCN(C6CCCCC6)CC5)=CC2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 527.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References

References are publications that support the biological activity of the product.

Kortagere et al (2018) Identification of novel allosteric modulators of glutamate transporter EAAT2. ACS Chem Neurosci. 9 522 PMID: 29140675


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Citations for GT 949

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