GSK 4716

Pricing Availability   Qty
Description: Selective ERRγ and ERRβ agonist
Alternative Names: GW4716
Chemical Name: 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
Purity: ≥99% (HPLC)
Citations (1)
Pathways (1)

Biological Activity for GSK 4716

GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and the classical estrogen receptors.

Technical Data for GSK 4716

M. Wt 282.34
Formula C17H18N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 101574-65-6
PubChem ID 5331325
Smiles OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 4716

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.23 100
ethanol 28.23 100

Preparing Stock Solutions for GSK 4716

The following data is based on the product molecular weight 282.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for GSK 4716

References are publications that support the biological activity of the product.

Zuercher et al (2005) Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J.Med.Chem. 48 3107 PMID: 15857113

Ariazi and Jordan (2006) Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr.Top.Med.Chem. 6 203 PMID: 16515477

Wang et al (2006) X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem. 281 37773 PMID: 16990259

If you know of a relevant reference for GSK 4716, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Agonists

Keywords: GSK 4716, GSK 4716 supplier, Selective, ERRγ, ERRgamma, ERRβ, ERRbeta, agonists, Estrogen, related, Receptors, GSK4716, GW4716, and, Related, 3075, Tocris Bioscience

1 Citation for GSK 4716

Citations are publications that use Tocris products. Selected citations for GSK 4716 include:

Weber et al (2014) Bisphenol A exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78 50 PMID: 25424546

Do you know of a great paper that uses GSK 4716 from Tocris? Please let us know.

Reviews for GSK 4716

There are currently no reviews for this product. Be the first to review GSK 4716 and earn rewards!

Have you used GSK 4716?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for GSK 4716

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.