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Biological Activity for GRP (porcine)
GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
Technical Data for GRP (porcine)
(Modifications: Met-27 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GRP (porcine)
|Solubility||Soluble to 1 mg/ml in water|
References for GRP (porcine)
References are publications that support the biological activity of the product.
Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID: 12540884
Schjoldager et al (1991) Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am.J.Physiol. 260 G577 PMID: 1708207
Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID: 12526815
Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223 PMID: 8602736
If you know of a relevant reference for GRP (porcine), please let us know.
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Keywords: GRP (porcine), GRP (porcine) supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Gastrin-releasing, peptide, (porcine), 1788, Tocris Bioscience
Citations for GRP (porcine)
Citations are publications that use Tocris products.
Currently there are no citations for GRP (porcine). Do you know of a great paper that uses GRP (porcine) from Tocris? Please let us know.
Reviews for GRP (porcine)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.