Granisetron hydrochloride

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Cat.No. 2903 - Granisetron hydrochloride | C18H24N4O.HCl | CAS No. 107007-99-8
Description: 5-HT3 antagonist
Alternative Names: BRL 43694
Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

5-HT3 receptor antagonist that possesses potent antiemetic activity.

Technical Data

M. Wt 348.87
Formula C18H24N4O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 107007-99-8
PubChem ID 65264
InChI Key QYZRTBKYBJRGJB-UHFFFAOYSA-N
Smiles O=C(C3=NN(C)C4=C3C=CC=C4)NC1CC(N2C)CCCC2C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.49 10
water 34.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 348.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.33 mL 28.66 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113 PMID: 2540014

Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805 PMID: 1723376

Martin et al (1998) Anti-emetic effect of Ondansetron and Granisetron after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631 PMID:


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Keywords: Granisetron hydrochloride, supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, BRL, 43694, 5-HT3, Receptors, Tocris Bioscience

2 Citations for Granisetron hydrochloride

Citations are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Neuropharmacology 7 2336 PMID: 26114334


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Reviews

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Granisetron hydrochloride

Protocols

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