Granisetron hydrochloride

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: 5-HT3 antagonist
Alternative Names: BRL 43694
Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Citations (4)
Literature (1)

Biological Activity for Granisetron hydrochloride

Granisetron hydrochloride is a 5-HT3 receptor antagonist that possesses potent antiemetic activity.

Technical Data for Granisetron hydrochloride

M. Wt 348.87
Formula C18H24N4O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 107007-99-8
PubChem ID 65264
Smiles O=C(C3=NN(C)C4=C3C=CC=C4)NC1CC(N2C)CCCC2C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Granisetron hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 34.89 100
DMSO 3.49 10

Preparing Stock Solutions for Granisetron hydrochloride

The following data is based on the product molecular weight 348.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.33 mL 28.66 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Granisetron hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Granisetron hydrochloride

References are publications that support the biological activity of the product.

Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113 PMID: 2540014

Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805 PMID: 1723376

Martin et al (1998) Anti-emetic effect of ondans. and granis. after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631

If you know of a relevant reference for Granisetron hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT3 Receptor Antagonists

Keywords: Granisetron hydrochloride, Granisetron hydrochloride supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, BRL, 43694, 2903, Tocris Bioscience

4 Citations for Granisetron hydrochloride

Citations are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Carlson and Fieber (2012) Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica. Comp Biochem Physiol C Toxicol Pharmacol 155 151 PMID: 21497673

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Neuropharmacology 7 2336 PMID: 26114334

Do you know of a great paper that uses Granisetron hydrochloride from Tocris? Please let us know.

Reviews for Granisetron hydrochloride

There are currently no reviews for this product. Be the first to review Granisetron hydrochloride and earn rewards!

Have you used Granisetron hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.