GR 79236

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Cat.No. 1957 - GR 79236 | C15H21N5O5 | CAS No. 124555-18-6
Description: A1 agonist
Chemical Name: N-[(1S,2S)-2-Hydroxycyclopentyl]adenosine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Adenosine A1 receptor agonist (Ki = 3.1 nM). Anticonvulsive in mice following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 351.36
Formula C15H21N5O5
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 124555-18-6
PubChem ID 9884817
InChI Key GYWXTRVEUURNEW-TVDBPQCTSA-N
Smiles O[C@@H](CCC4)[C@H]4NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.57 50
ethanol 3.51 10
water 35.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gurden et al (1993) Functional characterization of three adenosine receptor types. Br.J.Pharmacol. 109 693 PMID: 8358566

Knutsen et al (1999) N-Substituted adenosines as novel neuroprotective A1 agonists with diminished hypotensive effects. J.Med.Chem. 42 3463 PMID: 10479279

Merkel et al (1995) Cardiovascular and antilipolytic effects of the adenosine agonist GR 79236. Pharmacology 51 224 PMID: 8577816


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Keywords: GR 79236, supplier, A1, agonists, Receptors, adenosines, GR79236, GlaxoSmithKline, GSK, Adenosine, A1, Receptors, Adenosine, A1, Receptors, Tocris Bioscience

Citations for GR 79236

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