GR 231118

Pricing Availability Delivery Time Qty
Cat.No. 1486 - GR 231118 | Ile-Glu-Pro-Dpr-Tyr-Arg-Leu-Arg-Tyr-NH2 Ile-Glu-Pro-Dpr-Tyr-Arg-Leu-Arg-Tyr-NH2 (Disulfide bridges: 2 - 4*, 4 - 2*) | CAS No. 158859-98-4
Description: Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors
Alternative Names: 1229U91, GW 1229
Datasheet
Citations
Literature

Biological Activity

Potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 receptors respectively). Suppresses food intake in rats in vivo. Also has affinity for neuropeptide FF (NPFF) receptors in vitro (Ki = 43-73 nM).

Technical Data

M. Wt 2352.77
Formula C110H170N34O24
Sequence IEPXYRLRY IEPXYRLRY*

(Modifications: X = Dpr, Amide Bridge = 2 - 4*, 4 - 2*, Tyr-9 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 158859-98-4
PubChem ID 24868178
InChI Key RJRBRCCJETZJLT-GSICZYLSSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CCC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)NCC(NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@@H](N[H])[C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 2352.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.43 mL 2.13 mL 4.25 mL
5 mM 0.09 mL 0.43 mL 0.85 mL
10 mM 0.04 mL 0.21 mL 0.43 mL
50 mM 0.01 mL 0.04 mL 0.09 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Ishihara et al (1998) A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats. Am.J.Physiol. 274 R1500 PMID: 9612420

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1 PMID: 11325787

Parker et al (1998) GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur.J.Pharmacol. 349 97 PMID: 9669502


If you know of a relevant reference for GR 231118, please let us know.

Keywords: NPFF receptor ligands NPY Y1 antagonists Y4 agonists Neuropeptide FF GR231118 npffr1 npffr2 npff1 npff2 GW1229 1229 U91 neuropeptides 1229U91 GW 1229 NPY Receptors

Citations for GR 231118

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