GPP 78 hydrochloride
Biological Activity
Inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.
Compound Libraries
GPP 78 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 476.01 |
| Formula | C27H29N5O.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90488976 |
| InChI Key | WNZSQRVUGCAYDC-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.6 | 100 | |
| water | 47.6 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 476.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.1 mL | 10.5 mL | 21.01 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.1 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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References
References are publications that support the biological activity of the product.
Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616 PMID: 19961183
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.
