GPP 78 hydrochloride

Discontinued Product

GPP 78 hydrochloride (Cat. No. 4835) has been withdrawn from sale for commercial reasons.
Cat.No. 4835 - GPP 78 hydrochloride | C27H29N5O.HCl
Description: NAMPT inhibitor; also induces autophagy
Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (2)

Biological Activity for GPP 78 hydrochloride

GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data for GPP 78 hydrochloride

M. Wt 476.01
Formula C27H29N5O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488976
InChI Key WNZSQRVUGCAYDC-UHFFFAOYSA-N
Smiles O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for GPP 78 hydrochloride

References for GPP 78 hydrochloride

References are publications that support the biological activity of the product.

Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616 PMID: 19961183

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Keywords: GPP 78 hydrochloride, GPP 78 hydrochloride supplier, GPP78, hydrochloride, NMPRTase, NAMPT, NAD, nicotinamide, phosphoribosyltransferase, inhibitors, inhibits, autophagy, induces, inducers, Autophagy, 4835, Tocris Bioscience

1 Citation for GPP 78 hydrochloride

Citations are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:

Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867


Reviews for GPP 78 hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Great inhibitor..
By Anonymous on 05/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: human astrocytes

After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.

PMID: 31439867 Reference
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