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GPP 78 hydrochloride

Cat. No. 4835 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
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Cat.No. 4835 - GPP 78 hydrochloride | C27H29N5O.HCl
Description: NAMPT inhibitor; also induces autophagy
Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data

M. Wt 476.01
Formula C27H29N5O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488976
InChI Key WNZSQRVUGCAYDC-UHFFFAOYSA-N
Smiles O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 47.6 100
DMSO 47.6 100

Preparing Stock Solutions

The following data is based on the product molecular weight 476.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.5 mL 21.01 mL
5 mM 0.42 mL 2.1 mL 4.2 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References

References are publications that support the biological activity of the product.

Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616 PMID: 19961183

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1 Citation for GPP 78 hydrochloride

Citations are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:

Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867

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Reviews for GPP 78 hydrochloride

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Great inhibitor..
By Anonymous on 05/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: human astrocytes

After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.

PMID: 31439867 Reference
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