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Submit ReviewInhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.
M. Wt | 476.01 |
Formula | C27H29N5O.HCl |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
PubChem ID | 90488976 |
InChI Key | WNZSQRVUGCAYDC-UHFFFAOYSA-N |
Smiles | O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 47.6 | 100 | |
DMSO | 47.6 | 100 |
The following data is based on the product molecular weight 476.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.1 mL | 10.5 mL | 21.01 mL |
5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
10 mM | 0.21 mL | 1.05 mL | 2.1 mL |
50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
References are publications that support the biological activity of the product.
Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616 PMID: 19961183
If you know of a relevant reference for GPP 78 hydrochloride, please let us know.
Keywords: GPP 78 hydrochloride, GPP 78 hydrochloride supplier, GPP78, hydrochloride, NMPRTase, NAMPT, NAD, nicotinamide, phosphoribosyltransferase, inhibitors, inhibits, autophagy, induces, inducers, Autophagy, 4835, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:
Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867
Do you know of a great paper that uses GPP 78 hydrochloride from Tocris? Please let us know.
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After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.