GPP 78 hydrochloride

Discontinued Product

GPP 78 hydrochloride (Cat. No. 4835) has been withdrawn from sale for commercial reasons.
Description: NAMPT inhibitor; also induces autophagy
Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)
Literature (1)

Biological Activity for GPP 78 hydrochloride

GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data for GPP 78 hydrochloride

M. Wt 476.01
Formula C27H29N5O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488976

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for GPP 78 hydrochloride

References for GPP 78 hydrochloride

References are publications that support the biological activity of the product.

Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616 PMID: 19961183

View Related Products by Target

View Related Products by Product Action

View all NAMPT Inhibitors

Keywords: GPP 78 hydrochloride, GPP 78 hydrochloride supplier, GPP78, hydrochloride, NMPRTase, NAMPT, NAD, nicotinamide, phosphoribosyltransferase, inhibitors, inhibits, autophagy, induces, inducers, Autophagy, 4835, Tocris Bioscience

1 Citation for GPP 78 hydrochloride

Citations are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:

Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867

Reviews for GPP 78 hydrochloride

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used GPP 78 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Great inhibitor..
By Anonymous on 05/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: human astrocytes

After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.

PMID: 31439867 Reference
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.