GP 2a

Discontinued Product

GP 2a (Cat. No. 2678) has been withdrawn from sale for commercial reasons.
Description: Selective CB2 agonist
Chemical Name: N-Cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for GP 2a

GP 2a is a selective CB2 receptor agonist; Ki values are 7.6 and 900 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.

Technical Data for GP 2a

M. Wt 440.36
Formula C24H23Cl2N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 919077-81-9
PubChem ID 16094766
Smiles CC1=CC=C2C(CC3=C2N(N=C3C(=O)NC2CCCCC2)C2=CC=C(Cl)C=C2Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GP 2a

References are publications that support the biological activity of the product.

Murineddu et al (2006) Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxam J.Med.Chem. 49 7502 PMID: 17149879

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Keywords: GP 2a, GP 2a supplier, Selective, CB2, agonists, cannabinoids, Receptors, GP2a, cb2r, 2678, Tocris Bioscience

Citations for GP 2a

Citations are publications that use Tocris products.

Currently there are no citations for GP 2a.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.