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Submit ReviewGP 2a
Description: Selective CB2 agonist
Chemical Name: N-Cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
Purity: ≥99% (HPLC)
Biological Activity
Selective CB2 receptor agonist; Ki values are 7.6 and 900 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
Technical Data
| M. Wt | 440.36 |
| Formula | C24H23Cl2N3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 919077-81-9 |
| PubChem ID | 16094766 |
| InChI Key | SPEFJYZGXZENAF-UHFFFAOYSA-N |
| Smiles | CC1=CC=C2C(CC3=C2N(N=C3C(=O)NC2CCCCC2)C2=CC=C(Cl)C=C2Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.02 | 50 | |
| ethanol | 8.81 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 440.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.54 mL | 22.71 mL | 45.42 mL |
| 2.5 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.91 mL |
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References
References are publications that support the biological activity of the product.
Murineddu et al (2006) Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxam J.Med.Chem. 49 7502 PMID: 17149879
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Keywords: GP 2a, GP 2a supplier, Selective, CB2, agonists, cannabinoids, Receptors, GP2a, cb2r, 2678, Tocris Bioscience
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