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Submit ReviewGP 2a
Discontinued Product
GP 2a (Cat. No. 2678) has been withdrawn from sale for commercial reasons.
Description: Selective CB2 agonist
Chemical Name: N-Cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for GP 2a
GP 2a is a selective CB2 receptor agonist; Ki values are 7.6 and 900 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
Technical Data for GP 2a
| M. Wt | 440.36 |
| Formula | C24H23Cl2N3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 919077-81-9 |
| PubChem ID | 16094766 |
| InChI Key | SPEFJYZGXZENAF-UHFFFAOYSA-N |
| Smiles | CC1=CC=C2C(CC3=C2N(N=C3C(=O)NC2CCCCC2)C2=CC=C(Cl)C=C2Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GP 2a
References for GP 2a
References are publications that support the biological activity of the product.
Murineddu et al (2006) Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxam J.Med.Chem. 49 7502 PMID: 17149879
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Keywords: GP 2a, GP 2a supplier, Selective, CB2, agonists, cannabinoids, Receptors, GP2a, cb2r, 2678, Tocris Bioscience
Citations for GP 2a
Citations are publications that use Tocris products.
Currently there are no citations for GP 2a.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.