GP 2a

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Cat.No. 2678 - GP 2a | C24H23Cl2N3O | CAS No. 919077-81-9
Description: Selective CB2 agonist
Chemical Name: N-Cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective CB2 receptor agonist; Ki values are 7.6 and 900 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.

Technical Data

M. Wt 440.36
Formula C24H23Cl2N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 919077-81-9
PubChem ID 16094766
InChI Key SPEFJYZGXZENAF-UHFFFAOYSA-N
Smiles CC1=CC=C2C(CC3=C2N(N=C3C(=O)NC2CCCCC2)C2=CC=C(Cl)C=C2Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.02 50
ethanol 8.81 20

Preparing Stock Solutions

The following data is based on the product molecular weight 440.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.54 mL 22.71 mL 45.42 mL
2.5 mM 0.91 mL 4.54 mL 9.08 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

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References

References are publications that support the biological activity of the product.

Murineddu et al (2006) Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxam J.Med.Chem. 49 7502 PMID: 17149879


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Citations for GP 2a

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