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GoSlo SR 5-69
Biological Activity for GoSlo SR 5-69
GoSlo SR 5-69 is a BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).
Technical Data for GoSlo SR 5-69
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GoSlo SR 5-69
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GoSlo SR 5-69
The following data is based on the product molecular weight 470.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.13 mL||10.63 mL||21.26 mL|
|5 mM||0.43 mL||2.13 mL||4.25 mL|
|10 mM||0.21 mL||1.06 mL||2.13 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References for GoSlo SR 5-69
References are publications that support the biological activity of the product.
Roy et al (2014) Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. Eur.J.Med.Chem. 75 426 PMID: 24561672
Schewe et al (2019) A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 363 875 PMID: 30792303
If you know of a relevant reference for GoSlo SR 5-69, please let us know.
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Citations for GoSlo SR 5-69
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.