GoSlo SR 5-69

Pricing Availability   Qty
Description: KCa1.1 (BK) channel activator
Chemical Name: Sodium 1-Amino-9,10-dioxo-4-((5,6,7,8-tetrahydronaphthalen-2-yl)amino)-9,10-dihydroanthracene-2-sulfonate
Purity: ≥98% (HPLC)

Biological Activity for GoSlo SR 5-69

GoSlo SR 5-69 is a BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).

Technical Data for GoSlo SR 5-69

M. Wt 470.47
Formula C24H19N2NaO5S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1363419-31-1
PubChem ID 56944133
Smiles NC1=C2C(C3=CC=CC=C3C(C2=C(C=C1S(=O)([O-])=O)NC4=CC=C5CCCCC5=C4)=O)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GoSlo SR 5-69

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.05 100

Preparing Stock Solutions for GoSlo SR 5-69

The following data is based on the product molecular weight 470.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.63 mL 21.26 mL
5 mM 0.43 mL 2.13 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets for GoSlo SR 5-69

References for GoSlo SR 5-69

References are publications that support the biological activity of the product.

Roy et al (2014) Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. Eur.J.Med.Chem. 75 426 PMID: 24561672

Schewe et al (2019) A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 363 875 PMID: 30792303

If you know of a relevant reference for GoSlo SR 5-69, please let us know.

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Citations for GoSlo SR 5-69

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