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Submit ReviewGoSlo SR 5-69
Description: KCa1.1 (BK) channel activator
Chemical Name: Sodium 1-Amino-9,10-dioxo-4-((5,6,7,8-tetrahydronaphthalen-2-yl)amino)-9,10-dihydroanthracene-2-sulfonate
Purity: ≥98% (HPLC)
Biological Activity
BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).
Technical Data
| M. Wt | 470.47 |
| Formula | C24H19N2NaO5S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1363419-31-1 |
| PubChem ID | 56944133 |
| InChI Key | JOJJZTFRBZWSBX-UHFFFAOYSA-M |
| Smiles | NC1=C2C(C3=CC=CC=C3C(C2=C(C=C1S(=O)([O-])=O)NC4=CC=C5CCCCC5=C4)=O)=O.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.05 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 470.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.63 mL | 21.26 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Roy et al (2014) Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. Eur.J.Med.Chem. 75 426 PMID: 24561672
Schewe et al (2019) A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 363 875 PMID: 30792303
If you know of a relevant reference for GoSlo SR 5-69, please let us know.
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Keywords: GoSlo SR 5-69, GoSlo SR 5-69 supplier, GoSloSo5-69, SR569, BK, channels, activators, activates, Ca2+-Activated, Potassium, Channels, 5814, Tocris Bioscience
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