Goserelin acetate

Pricing Availability   Qty
Cat.No. 3592 - Goserelin acetate | Pyr-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NH-NH-CO-NH2 | CAS No. 145781-92-6
Description: GnRH receptor agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data

M. Wt 1269.42
Formula C59H84N18O14
Sequence XHWSYSLRP

(Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)

Storage Desiccate at -20°C
CAS Number 145781-92-6
PubChem ID 90488862
InChI Key BLCLNMBMMGCOAS-JFBCNRKLSA-N
Smiles [H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O)C(=O)C1CCC(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in water

References

References are publications that support the biological activity of the product.

Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091 PMID: 8033142

Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059 PMID: 8616851

Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254


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Keywords: Goserelin acetate, Goserelin acetate supplier, GnRH, receptor, antagonists, Receptors, gonadotropin, Gonadotrophin-Releasing, Hormone, ICI118630, chemotherapeutics, 3592, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Goserelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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