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Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.
(Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water|
References are publications that support the biological activity of the product.
Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091 PMID: 8033142
Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059 PMID: 8616851
Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254
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Keywords: Goserelin acetate, Goserelin acetate supplier, GnRH, receptor, antagonists, Receptors, gonadotropin, Gonadotrophin-Releasing, Hormone, ICI118630, chemotherapeutics, 3592, Tocris Bioscience
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