Goserelin acetate

Pricing Availability Delivery Time Qty
Cat.No. 3592 - Goserelin acetate | Pyr-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NH-NH-CO-NH2 | CAS No. 145781-92-6
Description: GnRH receptor agonist

Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data

M. Wt 1269.42
Formula C59H84N18O14

(Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)

Storage Desiccate at -20°C
CAS Number 145781-92-6
PubChem ID 90488862
Smiles [H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O)C(=O)C1CCC(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1269.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.79 mL 3.94 mL 7.88 mL
5 mM 0.16 mL 0.79 mL 1.58 mL
10 mM 0.08 mL 0.39 mL 0.79 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091 PMID: 8033142

Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059 PMID: 8616851

Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254 PMID:

If you know of a relevant reference for Goserelin acetate, please let us know.

View Related Products by Product Action

View all Gonadotropin-Releasing Hormone Receptor Agonists

Keywords: Goserelin acetate, supplier, GnRH, receptor, antagonists, Receptors, gonadotropin, Gonadotrophin-Releasing, Hormone, ICI118630, chemotherapeutics, Gonadotrophin-Releasing, Hormone, Receptors, Gonadotrophin-Releasing, Hormone, Receptors, Tocris Bioscience

Citations for Goserelin acetate

Citations are publications that use Tocris products.

Currently there are no citations for Goserelin acetate. Do you know of a great paper that uses Goserelin acetate from Tocris? If so please let us know.

Reviews for Goserelin acetate

There are currently no reviews for this product. Be the first to review Goserelin acetate and earn rewards!

Have you used Goserelin acetate?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing