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Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.19||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 237.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.41 mL||42.07 mL||84.14 mL|
|2.5 mM||1.68 mL||8.41 mL||16.83 mL|
|5 mM||0.84 mL||4.21 mL||8.41 mL|
|25 mM||0.17 mL||0.84 mL||1.68 mL|
References are publications that support the biological activity of the product.
Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059 PMID: 22948146
Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88 PMID: 21143836
If you know of a relevant reference for GMQ hydrochloride, please let us know.
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Keywords: GMQ hydrochloride, GMQ hydrochloride supplier, Selective, opener, acid-sensing, ion, channel, 3, ASIC3, ASIC1a, ASIC1b, ASIC, 5028, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.