GMQ hydrochloride

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Cat.No. 5028 - GMQ hydrochloride | C10H11N5.HCl | CAS No. 5361-15-9
Description: Selective ASIC3 opener
Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.

Technical Data

M. Wt 237.69
Formula C10H11N5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 5361-15-9
PubChem ID 12253739
InChI Key VNPZWQRWOHFAPD-UHFFFAOYSA-N
Smiles CC2=NC(NC(N)=N)=NC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.88 50
water 1.19 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 237.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.04 mL 42.07 mL
5 mM 0.84 mL 4.21 mL 8.41 mL
10 mM 0.42 mL 2.1 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059 PMID: 22948146

Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88 PMID: 21143836


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Keywords: GMQ hydrochloride, supplier, Selective, opener, acid-sensing, ion, channel, 3, ASIC3, ASIC1a, ASIC1b, ASIC, ASIC, Tocris Bioscience

Citations for GMQ hydrochloride

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Literature in this Area

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.