GMQ hydrochloride

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Cat.No. 5028 - GMQ hydrochloride | C10H11N5.HCl | CAS No. 5361-15-9
Description: Selective ASIC3 opener
Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity

Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.

Technical Data

M. Wt 237.69
Formula C10H11N5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 5361-15-9
PubChem ID 12253739
Smiles CC2=NC(NC(N)=N)=NC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.88 50
water 1.19 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 237.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.41 mL 42.07 mL 84.14 mL
2.5 mM 1.68 mL 8.41 mL 16.83 mL
5 mM 0.84 mL 4.21 mL 8.41 mL
25 mM 0.17 mL 0.84 mL 1.68 mL

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References are publications that support the biological activity of the product.

Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059 PMID: 22948146

Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88 PMID: 21143836

If you know of a relevant reference for GMQ hydrochloride, please let us know.

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Literature in this Area

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