Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.19||5mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 237.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.21 mL||21.04 mL||42.07 mL|
|5 mM||0.84 mL||4.21 mL||8.41 mL|
|10 mM||0.42 mL||2.1 mL||4.21 mL|
|50 mM||0.08 mL||0.42 mL||0.84 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059 PMID: 22948146
Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88 PMID: 21143836
If you know of a relevant reference for GMQ hydrochloride, please let us know.
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Keywords: Selective opener acid-sensing ion channel 3 ASIC3 ASIC1a ASIC1b ASIC
Citations for GMQ hydrochloride
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