Glycyl-H 1152 dihydrochloride

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Cat.No. 2485 - Glycyl-H-1152 dihydrochloride | C18H24N4O3S.2HCl | CAS No. 913844-45-8
Description: Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Technical Data

M. Wt 449.4
Formula C18H24N4O3S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 913844-45-8
PubChem ID 56972177
InChI Key ILDBNQGLZFSHQZ-UTLKBRERSA-N
Smiles CC1=CN=CC2=C1C(S(N3CCCN(C(CN)=O)C[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.47 50
water 44.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 449.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.13 mL 22.25 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tamura et al (2005) Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 1754 245 PMID: 16213195


If you know of a relevant reference for Glycyl-H 1152 dihydrochloride, please let us know.

View Related Products by Product Action

View all Rho-Kinases Inhibitors

Keywords: selective Rho-Associated Coiled-Coil Kinases ROCK p160ROCK ROK Rho-Kinases Rho-kinases

4 Citations for Glycyl-H 1152 dihydrochloride

Citations are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:

Sadaie et al (2015) Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 26 2971 PMID: 26133385

Lawrence et al (2015) Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys. Sci Rep 5 9092 PMID: 25766625

Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173 PMID: 25569349

Siegel et al (2010) Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet 19 3320 PMID: 20542987


Do you know of a great paper that uses Glycyl-H 1152 dihydrochloride from Tocris? If so please let us know.

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